Detection of paroxysmal nocturnal hemoglobinuria-phenotype in patients with chronic lymphocytic leukemia and multiple myeloma.

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dc.contributor.authorVarma, S
dc.contributor.authorVarma, N
dc.contributor.authorReddy, V V
dc.contributor.authorNaseem, S
dc.contributor.authorBose, P
dc.contributor.authorMalhotra, P
dc.date.accessioned2012-10-17T05:38:05Z
dc.date.available2012-10-17T05:38:05Z
dc.date.issued2012-04
dc.description.abstractBackground : Paroxysmal nocturnal hemoglobinuria (PNH) results due to decrease or absence of glycosylphosphatidylinositol-anchored (GPI) molecules, such as CD55 and CD59, from the surface of the affected cells. PNH-phenotype has been described in various hematological disorders, mainly aplastic anemia and myelodysplastic syndromes; recently it has been reported in patients with lymphoproliferative syndromes and multiple myeloma (MM). Materials and Methods : We evaluated the presence of CD55 negative and/or CD59 negative red blood cell (RBC) populations in newly diagnosed treatment naive-54 chronic lymphocytic leukemia (CLL) and 29 MM patients by flow cytometry. Results : PNH-phenotype was not reported in any patient; however, RBC populations deficient in CD55 were detected in 16.66% (9/54) CLL and 6.89% (2/29) MM patients. Clinical presentation or the hematological parameters did not show any relationship with the presence of CD55 deficient RBC population. Conclusion : Our study showed absence of PNH-phenotype in patients with CLL and MM; however, isolated CD55 deficient RBC were identified in both CLL and MM. Larger prospective studies by other centers, including simultaneous analysis of granulocytes for the presence of PNH-phenotype, are needed to corroborate these findings and to work out the mechanisms and the significance of the existence of this phenotype in these patients.en_US
dc.identifier.citationVarma S, Varma N, Reddy V V, Naseem S, Bose P, Malhotra P. Detection of paroxysmal nocturnal hemoglobinuria-phenotype in patients with chronic lymphocytic leukemia and multiple myeloma. Indian Journal of Pathology & Microbiology. 2012 Apr-Jun 55(2): 206-210.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142223
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=2;spage=206;epage=210;aulast=Varmaen_US
dc.subjectChronic lymphocytic leukemiaen_US
dc.subjectflow cytometryen_US
dc.subjectmultiple myelomaen_US
dc.subjectparoxsymal nocturnal hemoglobinuriaen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAntigens, CD55 --analysis
dc.subject.meshErythrocytes --chemistry
dc.subject.meshFemale
dc.subject.meshHemoglobinuria, Paroxysmal --diagnosis
dc.subject.meshHumans
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell --complications
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMultiple Myeloma --complications
dc.titleDetection of paroxysmal nocturnal hemoglobinuria-phenotype in patients with chronic lymphocytic leukemia and multiple myeloma.en_US
dc.typeArticleen_US
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