Hepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Bark

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dc.contributor.authorBabu, P. S.en_US
dc.contributor.authorKrishna, V.en_US
dc.contributor.authorBhavya, D. C.en_US
dc.date.accessioned2023-07-14T08:07:05Z
dc.date.available2023-07-14T08:07:05Z
dc.date.issued2023-02
dc.description.abstractAim of the Study: The phytoconstituent 6-heptadecylcyclohex 3-ene-1 carboxylic acid isolated from the methanol extract of Dichrotachys cinerea Wight. stem bark was evaluated for hepatoprotective activity against CCl4 induced toxicity. Materials and Methods: The constituent 6-heptadecylcyclohex 3-ene-1 carboxylic acid isolated from the methanolic extract of D. cinerea and the structure was confirmed by spectroscopic studies. Hepatoprotective property was screened in male wistar strain rats. The parameters studied were estimation of liver function serum markers such as serum total bilirubin, total protein, alanine transaminase, aspartate transaminase, alkaline phosphatase and histological profile of the liver tissue. Results: The LD50 of methanolic extract and constituent, 6-Heptadecylcyclohex -3-ene-1 carboxylic acid were evaluated and found to be 500 and 100 mg/kg body weight respectively. The hepatoprotective activity of constituent was more significant as similar to the standard hepatoprotective drug silymarin. The histological profile of the liver tissue showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration as similar to the controls. Conclusion: The methanolic extract of D. cinerea stem bark and the phytoconstituent 6-heptadecylcyclohex-3-ene-1 carboxylic acid showed significant protection from CCl4 induced liver damage.en_US
dc.identifier.affiliationsDepartment of Phytochemistry and Pharmacology Laboratory,Trans-Disciplinary ResearchFoundation, Shankaraghatta –577 451, Karnataka, Indiaen_US
dc.identifier.affiliationsP.G. Department of Studies and Research in Biotechnology and Bioinformatics, School of Biological Sciences, Kuvempu University, Shankaraghatta –577 451, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartmentofP.G. Studies and Research of Microbiology, University of Davanagere, 577002,Karnataka, Indiaen_US
dc.identifier.citationBabu P. S., Krishna V., Bhavya D. C.. Hepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Bark. European Journal of Medicinal Plants. 2023 Feb; 34(2): 24-33en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219538
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber2en_US
dc.relation.volume34en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2023/v34i21123en_US
dc.subjectDichrostachys cineriaen_US
dc.subjecthepatoprotectiveen_US
dc.subject6-Heptadecylcyclohex-3-ene-1 carboxylic aciden_US
dc.titleHepatoprotective Activity of 6-Heptadecylcyclohex -3-ene-1 Carboxylic Acid Isolated from the Methanol Extract of Dichrostachys cinerea Wight & Arn. Stem Barken_US
dc.typeJournal Articleen_US
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