Characteristics of Insulin and Androgen Status in Polycystic Ovary Syndrome.
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Date
2010
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Abstract
Polycystic Ovary Syndrome (PCOS) was originally described as a syndrome of
amenorrhea, hirsutism and obesity associated with enlarged polycystic ovaries. There is
increased androgen level and in some, insulin resistance (IR). Etiological relationship of
androgen excess and IR in PCOS is not established. Influence of obesity on PCOS is
controversial. This study was designed to see the androgen and insulin status in PCOS
among obese and non-obese patients. It was a case-control study. Of total 80 study
subjects, 60 primary infertile women suffering from PCOS were cases (30 obese and
30 non-obese). Age and BMI matched 20 healthy women having normal menstrual
cycles were controls (10 obese and 10 non-obese). Age range of all were 20-40 years.
Fasting plasma glucose, fasting S. Insulin and free Testosterone were measured. Insulin
resistance (IR) was assessed by fasting glucose to insulin ratio (<4.5). Subjects with
DM or known endocrine disorders that may be associated with abnormal S.Insulin or
plasma glucose concentration were excluded. No significant difference of fasting plasma
glucose between PCOS (obese or non-obese) and respective controls (P>0.5, in each)
were observed. Significant difference of fasting S. Insulin and testosterone were
observed between PCOS (both obese and non-obese) and respective controls (P<0.01
in each), but there was no significant difference between obese and non-obese PCOS
(P>0.05). There was no significant difference of S.Testosterone between obese and
non-obese PCOS(P>0.05). There was also no significant difference of IR between
obese and non-obese PCOS, but the ratio was <4.5 (indicating IR in both). There were
no significant correlation of S.Insulin with Testosterone in any group of PCOS (obese
and non-obese) (P>0.05). Increased S.Insulin and Testosterone was seen in PCOS
irrespective of BMI. Further studies with larger sample size is recommended to assess
etiological relationship between insulin and testosterone in PCOS.
Description
Keywords
PCOS (Polycystic Ovary Syndrome), S Insulin, S Testosterone, IR (Insulin Resisfance), Obesity
Citation
Banu L M, Wahab M A , Debnath B C, Begum D, Arslan M I. Characteristics of Insulin and Androgen Status in Polycystic Ovary Syndrome. Bangladesh Journal of Medical Biochemistry. 2010; 3(1): 11-15.