An analysis of children with typhoid fever admitted in 1991.

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dc.contributor.authorDeshmukh, C Ten_US
dc.contributor.authorNadkarni, U Ben_US
dc.contributor.authorKarande, S Cen_US
dc.date.accessioned1994-10-01en_US
dc.date.accessioned2009-06-02T12:22:16Z
dc.date.available1994-10-01en_US
dc.date.available2009-06-02T12:22:16Z
dc.date.issued1994-10-01en_US
dc.description.abstractIn 28 children, with bacteriologically and/or serologically diagnosed typhoid fever treated at KEM Hospital, Bombay in 1991, initially one of the three recommended drugs (viz. chloramphenicol, amoxycillin or co-trimoxazole) was given for 7 days for defervescence to occur. In those who failed to respond, a second trial of therapy with one of the other two drugs was initiated, after omitting the first drug. A second failure of therapy was taken as an indication to use ciprofloxacin singly. Eventually, 18 (64.3%) cases responded to chloramphenicol or amoxycillin or co-trimoxazole. Ciprofloxacin was used in 19(35.7%) cases. the failure rate of treatment with chloramphenicol was 50%, with amoxycillin 71.4%, with co-trimoxazole 75% and 0% with ciprofloxacin. An analysis of the 28 cases revealed that apart from fever (in 100%), splenomegaly (in 82.1%) was the most important clinical pointer to diagnosis, along with absolute eosinopenia (in 71.4%). There were no major complications, except 2 cases with typhoid hepatitis who responded to choramphenicol and co-trimoxazole, respectively. Blood culture grew Salmonella typhi in 7 cases, of which 5 (72%) were multidrug resistant S. typhi. There were no characteristic clinical features to identify multi-drug resistant typhoid fever.en_US
dc.description.affiliationDept. of Pediatrics, KEM Hospital, Parel, Bombay, Maharashtra.en_US
dc.identifier.citationDeshmukh CT, Nadkarni UB, Karande SC. An analysis of children with typhoid fever admitted in 1991. Journal of Postgraduate Medicine. 1994 Oct-Dec; 40(4): 204-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/116861
dc.language.isoengen_US
dc.source.urihttps://www.jpgmonline.comen_US
dc.subject.meshAmoxicillin --therapeutic useen_US
dc.subject.meshAnti-Infective Agents --therapeutic useen_US
dc.subject.meshChilden_US
dc.subject.meshCiprofloxacin --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshPenicillins --therapeutic useen_US
dc.subject.meshSplenomegalyen_US
dc.subject.meshTrimethoprim-Sulfamethoxazole Combination --therapeutic useen_US
dc.subject.meshTyphoid Fever --diagnosisen_US
dc.titleAn analysis of children with typhoid fever admitted in 1991.en_US
dc.typeJournal Articleen_US
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