The Effect of Postoperative Hepatic Fibrosis Factors on Morbidity in Mitral Valve Replacement Surgery: A Single Center Ten Years� Experience

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dc.contributor.authorYesiltas, Mehmet Alien_US
dc.contributor.authorAK, Hulya Yilmazen_US
dc.contributor.authorOzsahin, Yaseminen_US
dc.contributor.authorSandal, Barisen_US
dc.contributor.authorSalihoglu, Ziyaen_US
dc.contributor.authorErkalp, Keremen_US
dc.date.accessioned2023-07-14T08:01:17Z
dc.date.available2023-07-14T08:01:17Z
dc.date.issued2023-06
dc.description.abstractBackground: Previous studies have shown that hepatic fibrosis indices and rates can be used to predict cardiovascular mortality and morbidity. Our aim with this study was to investigate the effect of aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and fibrosis?4 (FIB?4) index calculated with ALT, AST, and platelet biomarkers, which are simple, fast, and relatively inexpensive and were used in previous studies to predict cardiovascular disease prognosis, on the prediction of postoperative morbidity and early mortality after mitral valve replacement (MVR) surgery. Methods: By scanning the hospital electronic health record system, 116 patients who underwent isolated MVR or MVR + tricuspid valve intervention were identified from 178 patients who underwent MVR with the standard sternotomy procedure between 2011 and 2021. The study was completed with 81 of these patients. Patients were divided into AST/ALT <2 (Group 1) and >2 (Group 2). In addition, the same patients were divided into FIB?4 index <3.25 (Group 3) and >3.25 (Group 4), and a total of four groups were formed. Results: The mean age of Group 2 was significantly higher than Group 1 (P = 0.049). In addition, the mean age of Group 4 was significantly higher than Group 3 (P = 0.003). Postoperative complications did not differ between Groups 1 and 2 (P > 0.05). While noninvasive mechanincal ventilation (NIMV) requirements did not differ between Groups 3 and 4 (P > 0.05), MV duration and intensive care unit stay were significantly longer in Group 4 (P < 0.05). Conclusion: The AST/ALT ratio, which has been shown to be a predictor of cardiovascular mortality in various studies, was not useful in predicting mortality and morbidity in our study. However, a high FIB?4 index, another hepatic fibrosis index, was found to be associated with increased perioperative bleeding, duration of mechanical ventilation, and cardiac intensive care unit stay, which are important criteria in the prediction of morbidity in cardiovascular surgery.en_US
dc.identifier.affiliationsDepartment of Cardiovascular Surgery, Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospitalen_US
dc.identifier.affiliationsDepartment of Anesthesiology and Reanimation, University of Health Sciences Kartal Dr. L黷fi Kirdar Training and Research Hospitalen_US
dc.identifier.affiliationsDepartment of Anesthesiology and Reanimation, Istanbul University-Cerrahpasa, Cardiology Instituteen_US
dc.identifier.affiliationsDepartment of Biostatistics, Istanbul University-Cerrahpasa, Istanbul, Turkeyen_US
dc.identifier.citationYesiltas Mehmet Ali, AK Hulya Yilmaz, Ozsahin Yasemin, Sandal Baris, Salihoglu Ziya, Erkalp Kerem. The Effect of Postoperative Hepatic Fibrosis Factors on Morbidity in Mitral Valve Replacement Surgery: A Single Center Ten Years� Experience. International Journal of Medical Research & Health Sciences. 2023 Jun; 26(2): 190-196en_US
dc.identifier.issn0974-5181
dc.identifier.issn0971-9784
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219295
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume26en_US
dc.source.urihttps://doi.org/10.4103/aca.aca_55_22en_US
dc.subjectIntensive careen_US
dc.subjecthepatic fibrosisen_US
dc.subjectliver enzymesen_US
dc.subjectmechanical ventilationen_US
dc.subjectmitral valve replacementen_US
dc.titleThe Effect of Postoperative Hepatic Fibrosis Factors on Morbidity in Mitral Valve Replacement Surgery: A Single Center Ten Years� Experienceen_US
dc.typeJournal Articleen_US
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