A Study on Immunosuppressant Induced Dyslipidemia and Associated Chronic Graft Rejection in Renal Transplant Recipients.

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dc.contributor.authorGeorge, P Samuel Gideon
dc.contributor.authorDhivya, K
dc.date.accessioned2016-09-06T09:34:59Z
dc.date.available2016-09-06T09:34:59Z
dc.date.issued2016-04
dc.description.abstractDyslipidemia is a common complication of renal transplantation referred to as new onset dyslipidemia. Immune suppressants, in particular cyclosporine, the calcineurin inhibitor and others are known to cause dyslipidemia through non-competitive inhibition of sterol 27-dehydroxylase (CYP27A1). On the other hand, dyslipidemia has been found to be associated with higher graft rejection due to decrease in immune suppressant activity and direct graft destruction. Hence the study was designed to analyze the effect of dyslipidemia on chronic allograft rejection. Clinical and biochemistry reports of 142 renal transplant recipients were collected in designed case report forms. All statistical analysis was carried out using International Business Machine (IBM) Statistical Package for Social Sciences (SPSS) 17.0. Immunosuppressive therapy, comorbid diabetes and hypertension, age and serum creatinine were found to be the common predictors of dyslipidemia whereas as dyslipidemia, age and gender were found to be predictors of graft destruction and loss (P>0.05). Incidence of graft loss was found higher in dyslipidemic patients (P<0.05). Dyslipidemia is associated with higher incidence of graft loss and hence renal transplant recipients should be effectively managed with dose intense statin therapy or other safer immunosuppressants. This could increase graft survival rates.en_US
dc.identifier.citationGeorge P Samuel Gideon, Dhivya K. A Study on Immunosuppressant Induced Dyslipidemia and Associated Chronic Graft Rejection in Renal Transplant Recipients. Journal of Applied Pharmaceutical Science. 2016 Apr; 6(4): 183-189.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176984
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1847en_US
dc.subjectRenal transplanten_US
dc.subjectimmunosuppressanten_US
dc.subjectmetabolic syndromeen_US
dc.subjectdyslipidemiaen_US
dc.subjectgraft rejectionen_US
dc.titleA Study on Immunosuppressant Induced Dyslipidemia and Associated Chronic Graft Rejection in Renal Transplant Recipients.en_US
dc.typeArticleen_US
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