Concurrent increased high sensitivity C-reactive protein and chronic infections are associated with coronary artery disease: a population-based study.

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dc.contributor.authorVahdat, Katayonen_US
dc.contributor.authorJafari, Seyed Mojtabaen_US
dc.contributor.authorPazoki, Rahaen_US
dc.contributor.authorNabipour, Irajen_US
dc.date.accessioned2007-03-06en_US
dc.date.accessioned2009-05-29T06:00:28Z
dc.date.available2007-03-06en_US
dc.date.available2009-05-29T06:00:28Z
dc.date.issued2007-03-06en_US
dc.description.abstractBACKGROUND: An elevated serum level of C-reactive protein (CRP) is an independent predictor of coronary artery disease (CAD). Chronic infections have also been implicated in the pathogenesis of CAD. AIMS: To investigate how concomitant chronic infection and CRP related to electrocardiogram-defined CAD in a general population. SETTING AND DESIGN: A population-based cross-sectional study, which was conducted in three Iranian ports in the northern Persian Gulf. MATERIALS AND METHODS: For evaluation of CAD, we used Minnesota coding criteria of a 12-lead resting electrocardiogram in 1,754 subjects, aged 25 years and over, selected by cluster random sampling. Sera were analyzed for IgG antibodies to Chlamydia pneumoniae (C. pneumoniae), Herpes simplex virus type 1 (HSV-1), Helicobacter pylori (H. pylori) and cytomegalovirus (CMV) using ELISA. Measurement of CRP by a high-sensitivity CRP assay was done. STATISTICAL ANALYSIS: Multiple logistic regression analysis was used. RESULTS: None of the infectious agents (CMV, H. pylori, C. pneumoniae and HSV-1) showed a significant association with electrocardiogram-defined CAD after adjusting for sex and age. Elevated CRP levels did not show significant association with electrocardiogram-defined CAD independent of seropositivity to one of the four infectious agents, but concurrent elevated CRP levels (>10.0 mg/L) and anti-C. pneumoniae [OR = 1.68 (CI, 1.24-2.59; P=0.04)], H. pylori [OR = 1.98 (CI, 1.26-3.13; P=0.003)], CMV [OR = 1.66 (CI, 1.10-2.49; P=0.01)] or HSV-1 [OR=1.79 (CI, 1.18-2.72; P=0.006)] IgG antibodies were associated with prevalence of electrocardiogram-defined CAD in the general population, after adjustment for multiple risk factors, including age, sex and the components of the metabolic syndrome. CONCLUSIONS: Beyond traditional cardiovascular risk factors, concomitant chronic infection and elevated CRP are significantly correlated with electrocardiogram-defined CAD.en_US
dc.description.affiliationDepartment of Internal Medicine, School of Medicine, The Persian Gulf Health Research Center, Iran.en_US
dc.identifier.citationVahdat K, Jafari SM, Pazoki R, Nabipour I. Concurrent increased high sensitivity C-reactive protein and chronic infections are associated with coronary artery disease: a population-based study. Indian Journal of Medical Sciences. 2007 Mar; 61(3): 135-43en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/68311
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBiological Markers --analysisen_US
dc.subject.meshC-Reactive Protein --analysisen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshCoronary Artery Disease --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfection --blooden_US
dc.subject.meshIran --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPopulationen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.titleConcurrent increased high sensitivity C-reactive protein and chronic infections are associated with coronary artery disease: a population-based study.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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