Distribution of HIV-1 resistance-conferring polymorphic alleles SDF-1-3'A, CCR2-64I and CCR5-Delta32 in diverse populations of Andhra Pradesh, South India.

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dc.contributor.authorRamana, G Ven_US
dc.contributor.authorVasanthi, Aen_US
dc.contributor.authorKhaja, Men_US
dc.contributor.authorSu, Ben_US
dc.contributor.authorGovindaiah, Ven_US
dc.contributor.authorJin, Len_US
dc.contributor.authorSingh, Len_US
dc.contributor.authorChakraborty, Ren_US
dc.date.accessioned2001-12-04en_US
dc.date.accessioned2009-06-02T07:07:48Z
dc.date.available2001-12-04en_US
dc.date.available2009-06-02T07:07:48Z
dc.date.issued2001-12-04en_US
dc.description.abstractPolymorphic allelic variants of chemokine receptors CCR2 and CCR5, as well as of stromal-derived factor-1 SDF-1, the ligand for the chemokine receptor CXCR4, are known to have protective effects against HIV-1 infection and to be involved with delay in disease progression. We have studied the DNA polymorphisms at the loci that encode these proteins in 525 healthy individuals without any history of HIV-1 infection from 11 diverse populations of Andhra Pradesh, South India. The two protective alleles SDF-1-3'A and CCR2-64I at the SDF-1 and CCR2 loci, respectively, are present in all populations studied, although their frequencies differ considerably across populations (from 17% to 35% for the SDF-1-3'A allele, and from 3% to 17% for CCR2-64I). In contrast the CCR5-Delta32 allele is observed only in three populations (Yamani, Pathan and Kamma), all in low frequencies (i.e. 1% to 3%). The mean number of mutant alleles (for the three loci together) carried by each individual varies from 0.475 (in Vizag Brahmins) to 0.959 (in Bohra Muslims). The estimated relative hazard values for the populations, computed from the three-locus genotype data, are comparable to those from Africa and Southeast Asia, where AIDS is known to be widespread.en_US
dc.description.affiliationHuman Genetics Center, School of Public Health, University of Texas, P.O. Box 20186, Houston, TX 77225, USA.en_US
dc.identifier.citationRamana GV, Vasanthi A, Khaja M, Su B, Govindaiah V, Jin L, Singh L, Chakraborty R. Distribution of HIV-1 resistance-conferring polymorphic alleles SDF-1-3'A, CCR2-64I and CCR5-Delta32 in diverse populations of Andhra Pradesh, South India. Journal of Genetics. 2001 Dec; 80(3): 137-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/114234
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jgenet/index.htmlen_US
dc.subject.meshAcquired Immunodeficiency Syndrome --geneticsen_US
dc.subject.meshAllelesen_US
dc.subject.meshChemokine CXCL12en_US
dc.subject.meshChemokines, CXC --geneticsen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHIV Infections --geneticsen_US
dc.subject.meshHIV-1en_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --ethnologyen_US
dc.subject.meshMutationen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, CCR2en_US
dc.subject.meshReceptors, CCR5 --geneticsen_US
dc.subject.meshReceptors, Chemokine --geneticsen_US
dc.titleDistribution of HIV-1 resistance-conferring polymorphic alleles SDF-1-3'A, CCR2-64I and CCR5-Delta32 in diverse populations of Andhra Pradesh, South India.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
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