Morning steroid profile in children with congenital adrenal hyperplasia under different hydrocortisone schedules.

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dc.contributor.authorSilva, I Nen_US
dc.contributor.authorOliveira-JĂșnior, D Fen_US
dc.contributor.authorSimal, C Jen_US
dc.contributor.authorViana, M Ben_US
dc.contributor.authorChagas, A Jen_US
dc.date.accessioned1994-07-01en_US
dc.date.accessioned2009-05-30T13:46:07Z
dc.date.available1994-07-01en_US
dc.date.available2009-05-30T13:46:07Z
dc.date.issued1994-07-01en_US
dc.description.abstractWe studied 13 children with 21-hydroxyalse deficiency to explore the immediate potential suppressive effect of hydrocortisone dose schedule on the adrenal cortex. They were given 20 mg/m2 daily in a controlled trial. After random administration of a greater dose in the morning (7 patients) or at night (6 patients), we measured plasma levels of 17-hydroxyprogesterone, testosterone, and androstenedione at times-24, 0, 2, 4, and 6h. Considerable fluctuation of the steroid levels, unrelated to the drug intake, was observed. There was no statistically significant differences between the "morning dose" and "night dose" groups for any steroid. We conclude that; (i) the greater night dose did not avoid the 17-hydroxyprogesterone morning peaks, and (ii) the variation in plasma steroid levels is so marked that a single morning sample is unreliable to reflect the degree of adrenal suppression.en_US
dc.description.affiliationPediatric Department of Medical School, Federal University of Minas Gerais, Brasil.en_US
dc.identifier.citationSilva IN, Oliveira-JĂșnior DF, Simal CJ, Viana MB, Chagas AJ. Morning steroid profile in children with congenital adrenal hyperplasia under different hydrocortisone schedules. Indian Journal of Pediatrics. 1994 Jul-Aug; 61(4): 341-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82010
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.mesh17-alpha-Hydroxyprogesteroneen_US
dc.subject.meshAdrenal Cortex --drug effectsen_US
dc.subject.meshAdrenal Hyperplasia, Congenital --drug therapyen_US
dc.subject.meshAndrostenedione --blooden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisone --administration & dosageen_US
dc.subject.meshHydroxyprogesterones --blooden_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshTestosterone --blooden_US
dc.titleMorning steroid profile in children with congenital adrenal hyperplasia under different hydrocortisone schedules.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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