The Influence of Telmisartan on Metabolic Parameters in Hypertensive Patients of Metabolic Syndrome- A Prospective Study.
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Date
2016-11
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Abstract
Background: Telmisartan, an angiotensin II receptor blocker, has a higher affinity for AT1 receptors. It has also been
recognized as partial agonist of the nuclear hormone receptor PPAR-gamma. The present study is conducted to study the
effect of telmisartan on various metabolic parameters in hypertensive patients who have satisfied the standards of
metabolic syndrome. Methods: This is a prospective and randomised study done on twenty hypertensive patients suffering
from metabolic syndrome. All the patients underwent following investigations like Fasting plasma glucose, post prandial
plasma glucose, HbA1c levels, lipid profile including total triglyceride, LDL, total cholesterol and HDL, C-peptide level, blood
pressure, body mass index and weight were also measured. All the patients were recommended 40 mg of telmisartan
orally every day. The above mentioned investigations were repeated after 4 months. Data was tabulated and compared
with the previous readings by using paired t- test and P value < 0.05 was considered significant. Results: The change in
both weight and body mass index is statistically insignificant. All the three haemodynamic parameters (SBP, DBP, MAP)
showed significant decrease after intake of 40 mg telmisartan for four months. All the parameters (Total cholesterol, LDL,
Triglycerides) of lipid profile of the patients except HDL demonstrated decrease in value. Regarding glucose metabolism,
fasting c- peptide level, glycosylated haemoglobin concentration showed no difference in the value, whereas both fasting
and post prandial blood glucose decreased significantly. Conclusion: The present study proves that telmisartan has
agonistic and modulating action on PPAR Gamma receptor and is thus associated with lipid and glucose metabolism.
Description
Keywords
Hypertension, Metabolic syndrome, Telmisartan
Citation
Singhal Alok, Singhal Manas, Singh Vinod Kumar. The Influence of Telmisartan on Metabolic Parameters in Hypertensive Patients of Metabolic Syndrome- A Prospective Study. Annals of International Medical and Dental Research. 2016 Nov-Dec; 2(6): 59-62.