Histopathological Profile of Obese Zebrafish Liver after Administration of Red Spinach (Amaranthus tricolor L.)

Simple item page
dc.contributor.authorYuniarto, A.en_US
dc.contributor.authorPutri, A. Z.en_US
dc.contributor.authorSelifiana, N.en_US
dc.contributor.authorMegawati, S.en_US
dc.contributor.authorRangkuti, S. N.en_US
dc.contributor.authorAdnyana, I. K.en_US
dc.date.accessioned2023-07-14T08:07:05Z
dc.date.available2023-07-14T08:07:05Z
dc.date.issued2023-03
dc.description.abstractAims: Obesity is a non-communicable disease whose prevalence continues to increase every year throughout the world. Obesity contributes to the emergence of several diseases such as type-2 diabetes mellitus, hypertension, cardiovascular disorders, cancer, and non-alcoholic fatty liver. A number of studies report that natural ingredients have the potential to be used as a treatment for obesity while reducing a fatty liver. The aim of this research is to evaluate the activity of red spinach ethanol extract in reducing the accumulation of fatty liver in diet-induced obese zebrafish based on its histopathological profile. Methodology: Zebrafish must be adapted for 2 weeks. After 2 weeks, the zebrafish were divided into 6 groups which included: the normal group (or negative control); the obesity group (positive control group); the standard drug (orlistat with dose 4.5 µg/ml); the EERS group (dose of 50 µg/ml); the EERS group (dose of 100 µg/ml); and the EERS group (dose of 200 µg/ml). For a period of 4 weeks, the normal group received a standard diet. A positive control group received Artemia. The treated group received Artemia which was combined with the administration of red spinach (preventive method). The obese group and extract-treated group were given 60 mg/group/fish in the experimental diet. Results: The results showed that EERS at a dose of 100 µg/ml did not show any fatty liver based on their histopathological profile. The EERS dose of 200 µg/ml is more effective in reducing fatty liver when compared to doses of 50 µg/ml and 100 µg/ml on obese zebrafish. Conclusion: Based on the results of the study, it can be concluded that EERS is very prospective for further research and development as a drug for treating obesity and reducing fatty liver.en_US
dc.identifier.affiliationsFaculty of Pharmacy, Muhammadiyah A.R. Fachruddin University, Tangerang, Indonesiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Bhakti Kencana University, Bandung, Indonesiaen_US
dc.identifier.affiliationsSchool of Pharmacy, Bandung Institute of Technology, Bandung, Indonesiaen_US
dc.identifier.citationYuniarto A., Putri A. Z., Selifiana N., Megawati S., Rangkuti S. N., Adnyana I. K.. Histopathological Profile of Obese Zebrafish Liver after Administration of Red Spinach (Amaranthus tricolor L.). European Journal of Medicinal Plants. 2023 Mar; 34(3): 40-44en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219541
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber3en_US
dc.relation.volume34en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2023/v34i31128en_US
dc.subjectHistopathologicalen_US
dc.subjectobeseen_US
dc.subjectred spinachen_US
dc.subjectzebrafishen_US
dc.titleHistopathological Profile of Obese Zebrafish Liver after Administration of Red Spinach (Amaranthus tricolor L.)en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
EJMP2023v34n3p40.pdf
Size:
474.68 KB
Format:
Adobe Portable Document Format
Download
Collections
European Journal of Medicinal Plants