APO-1/Fas gene: Structural and functional characteristics in systemic lupus erythematosus and other autoimmune diseases.

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dc.contributor.authorSingh, Richa
dc.contributor.authorPradhan, Vandana
dc.contributor.authorPatwardhan, Manisha
dc.contributor.authorGhosh, K
dc.date.accessioned2012-06-08T03:58:31Z
dc.date.available2012-06-08T03:58:31Z
dc.date.issued2009-09
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disorder affecting multiple organ systems. It is characterized by the presence of autoantibodies reactive against various self-antigens. Susceptibility to SLE is found to be associated with many major histocompatibility complex (MHC) and non-MHC genes, one of which is APO-1/Fas gene, which is present on chromosome 10 in humans. The APO-1/Fas promoter contains consensus sequences for binding of several transcription factors that affect the intensity of Fas expression in cells. The mutations in the APO-1/Fas promoter are associated with risk and severity in various autoimmune diseases and other malignancies. The APO-1/Fas receptor is expressed by many cell types. Two forms of APO-1/Fas protein that are involved in regulation of apoptosis have been identified. Fas receptor-mediated apoptosis plays a physiological and pathological role in killing of infected cell targets. In this review, we have focused on APO-1/Fas gene structure, promoter variants and its association with SLE and other autoimmune diseases. Functional aspects of Fas receptor in apoptosis are also discussed.en_US
dc.identifier.citationSingh Richa, Pradhan Vandana, Patwardhan Manisha, Ghosh K. APO-1/Fas gene: Structural and functional characteristics in systemic lupus erythematosus and other autoimmune diseases. Indian Journal of Human Genetics. 2009 Sept; 15(3): 98-102.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/138880
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922636/en_US
dc.subjectAPO-1/Fas promoteren_US
dc.subjectautoimmune diseasesen_US
dc.subjectsystemic lupus erythematosusen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntigens, CD95 --genetics
dc.subject.meshApoptosis --genetics
dc.subject.meshAutoimmune Diseases --genetics
dc.subject.meshChromosomes, Human, Pair 10 --genetics
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLupus Erythematosus, Systemic --epidemiology
dc.subject.meshLupus Erythematosus, Systemic --genetics
dc.subject.meshRecombinant Fusion Proteins --genetics
dc.titleAPO-1/Fas gene: Structural and functional characteristics in systemic lupus erythematosus and other autoimmune diseases.en_US
dc.typeArticleen_US
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