Ultrastructural features of sidero - apoptotic hepatocytes in thalassemia.
| dc.contributor.author | Thakerngpol, Kleophant | |
| dc.contributor.author | Khawcharoenporn, Vanneet | |
| dc.contributor.author | Mangkalanond, Kaewkanjana | |
| dc.contributor.author | Choosrichom, Naree | |
| dc.contributor.author | Buawatana, Chaiyoot | |
| dc.contributor.author | Sookpatdhee, Vicha | |
| dc.contributor.author | Fucharoen, Suthat | |
| dc.contributor.author | Stitnimankarn, Tinrat | |
| dc.date.accessioned | 2012-03-30T08:22:32Z | |
| dc.date.available | 2012-03-30T08:22:32Z | |
| dc.date.issued | 2001-08 | |
| dc.description.abstract | Liver tissues from 20 patients with thalassemia were investigated by light and electron microscopy, with focus on ultrastructure of sidero-apoptosis. The results of light microscopy were compared. Sidero-apoptosis was found in 82% in b thal/Hb E disease, 67% in thalassemia Hb H, 100% in and b-thal major, respectively. Regardless of the type of hemoglobin, sidero-apoptosis was present in various degrees. The main criteria used for identification of sidero-apoptosis were marked condensation of chromatin against the nuclear membrane, and fragmentation into nuclear fragments of varying sizes and structures into membrane-bounded sidero-apop-totic bodies. These bodies may be phagocytosed by macrophages or neighboring cells or remain free. However, the cell may also shrink into a dense, rounded mass, as a single sidero-apoptotic body. Sidero-apoptoic bodies were similar to acidophilic bodies, or Councilman bodies, commonly found in viral hepatitis. This preliminary report suggestsd that sidero-apoptosis is a features of human liver pathology in thalassemia and may be due to hepatotoxicity of iron overload. In addition, many factors or other agents-hormone, killer cells, cytokines, various physical, chemical and viral agents should be considered. We propose the term "sidero-apoptosis" to describe the features resenbling acidophilic bodies commonly seen in viral hepatitis but with a heavy depositi of iron. | en_US |
| dc.identifier.citation | Thakerngpol Kleophant, Khawcharoenporn Vanneet, Mangkalanond Kaewkanjana, Choosrichom Naree, Buawatana Chaiyoot, Sookpatdhee Vicha, Fucharoen Suthat, Stitnimankarn Tinrat. Ultrastructural features of sidero - apoptotic hepatocytes in thalassemia. Siriraj Medical Journal, 2001 Aug; 53(8): 502-508. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/137407 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.sirirajmedj.com/content_download.php?content_id=911 | en_US |
| dc.subject | Ultrastructure | en_US |
| dc.subject | Sidero - apoptotic | en_US |
| dc.subject | Hepatocytes | en_US |
| dc.subject | Thalassemia | en_US |
| dc.title | Ultrastructural features of sidero - apoptotic hepatocytes in thalassemia. | en_US |
| dc.type | Article | en_US |