Impact of COVID-19 infection on pregnancy outcomes: A retrospective cohort study focusing on preterm and low-birth-weight pregnancies

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dc.contributor.authorChowdary, NDen_US
dc.contributor.authorSridhar, CMen_US
dc.contributor.authorKantharajanna, Uen_US
dc.contributor.authorNaidu, Sen_US
dc.contributor.authorVenkatesh, Sen_US
dc.contributor.authorMenon, AS.en_US
dc.date.accessioned2025-08-13T09:57:11Z
dc.date.available2025-08-13T09:57:11Z
dc.date.issued2025-01
dc.description.abstractIntroduction: Viral infections pose significant risks to pregnant women and fetuses. Although the impact of many viruses on pregnancy has been well-documented, the specific effects of COVID-19 on gestational age and newborn development remain unclear. There is a need to investigate these relationships in an Indian context where data on COVID-19 and pregnancy outcomes are limited. Aim: To determine the effect of COVID-19 infection on gestational age and birth weight in neonates born to COVID- 19-positive mothers during the third trimester of gestation. Materials and Methods: This retrospective cohort study used medical records collected from March 2020 to September 2022 at a tertiary hospital in Bengaluru. The data were analyzed in 2023. A total of 379 pregnant women aged 18–35 years were included in the study, out of which 325 were COVID-19 positive, while 54 were COVID-19 negative. In all the study subjects, comorbidities, gestational age, birth weight, and infection severity were recorded and analyzed. The chi-square test and Mood’s median test were used to compare COVID-19-positive pregnant women with COVID-19-negative pregnant women who delivered during the same time period. Results: COVID-19 infected women had an average gestational age of 269.24 ± 16.11 days compared to noninfected women 270.33 ± 10.65 days with a p-value of 0.733. Approximately 13.84% (45) of COVID-19-positive women delivered their babies preterm. The study found that the average birth weight of babies born to COVID-19 infected mothers was 2.78 ± 0.53 kg compared to 2.81 ± 0.4 kg in noninfected mothers with a p-value of 0.637 and the birth weights in both groups were comparable to the average birth weight in India. Conclusion: The study found that COVID-19 did not appear to increase the likelihood of adverse pregnancy outcomes, such as preterm delivery or low birth weight, in the studied population, suggesting that it does not pose a specific threat to the health of the mother or fetus.en_US
dc.identifier.affiliationsShri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore, Indiaen_US
dc.identifier.affiliationsShri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore, Indiaen_US
dc.identifier.affiliationsShri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore, Indiaen_US
dc.identifier.affiliationsShri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore, Indiaen_US
dc.identifier.affiliationsShri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore, Indiaen_US
dc.identifier.affiliationsShri Atal Bihari Vajpayee Medical College and Research Institute, Bangalore, Indiaen_US
dc.identifier.citationChowdary ND, Sridhar CM, Kantharajanna U, Naidu S, Venkatesh S, Menon AS.. Impact of COVID-19 infection on pregnancy outcomes: A retrospective cohort study focusing on preterm and low-birth-weight pregnancies . National Journal of Physiology, Pharmacy and Pharmacology. 2025 Jan; 15(1): 20-27en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252838
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber1en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org/10.5455/NJPPP.2025.v15.i1.4en_US
dc.subjectViral infectionsen_US
dc.subjectGestational ageen_US
dc.subjectIntrauterine viral transmissionen_US
dc.subjectGrowth restrictionen_US
dc.subjectPlacental barrieren_US
dc.titleImpact of COVID-19 infection on pregnancy outcomes: A retrospective cohort study focusing on preterm and low-birth-weight pregnanciesen_US
dc.typeJournal Articleen_US
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