Effect of theophylline on binding of delta-9-tetrahydrocannabinol with mammalian neuronal and non-neuronal membranes.

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dc.contributor.authorGhosh, S Ken_US
dc.contributor.authorPoddar, M Ken_US
dc.date.accessioned2009-05-28T15:06:58Z
dc.date.available2009-05-28T15:06:58Z
dc.date.issued1993-02-01en_US
dc.description.abstractDelta-9-tetrahydrocannabinol (THC) (1.6 x 10(-6)-13.33 x 10(-6) M) binds to neuronal and non-neuronal subcellular membranes in a biphasic manner. Its binding to neuronal membranes occur in the following order synaptosome > myelin > brain microsome and brain mitochondria. Unlike brain membranes binding of delta-9-THC is greater with liver microsome than liver mitochondria. Irrespective of membranes theophylline (Th) (11.0 x 10(-6) and 550.0 x 10(-6) M) increases the binding of delta-9-THC by exposure of more number of delta-9-THC binding sites on the subcellular membranes without affecting its binding affinity. Failure of Th (11.0 x 10(-6)-550.0 x 10(-6) M) to increase the binding of delta-9-THC (1.6 x 10(-6)-13.33 x 10(-6) M) in solubilized membranes suggests the involvement of membrane lipid in the Th-induced enhancement of delta-9-THC binding.en_US
dc.description.affiliationDepartment of Biochemistry, University of Calcutta, India.en_US
dc.identifier.citationGhosh SK, Poddar MK. Effect of theophylline on binding of delta-9-tetrahydrocannabinol with mammalian neuronal and non-neuronal membranes. Indian Journal of Experimental Biology. 1993 Feb; 31(2): 130-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61574
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain --metabolismen_US
dc.subject.meshIntracellular Membranes --drug effectsen_US
dc.subject.meshLiver --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurons --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshTetrahydrocannabinol --metabolismen_US
dc.subject.meshTheophylline --pharmacologyen_US
dc.titleEffect of theophylline on binding of delta-9-tetrahydrocannabinol with mammalian neuronal and non-neuronal membranes.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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