Comparative evaluation of beta-blockers with or without statins in the treatment of essential hypertension at a tertiary health care setup.

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dc.contributor.authorBawa, Shalu
dc.contributor.authorDutta, Shakti B
dc.contributor.authorKumar, Hitender
dc.contributor.authorBeg, Mirza Atif
dc.contributor.authorVarma, Amit
dc.contributor.authorAnjoom, Mohammad
dc.date.accessioned2015-11-04T05:06:01Z
dc.date.available2015-11-04T05:06:01Z
dc.date.issued2015-01
dc.description.abstractBackground: The effects of statins apart from their role as cholesterol lowering agents have prompted this study to evaluate their antihypertensive role. Beta-blockers (BB) are one of the most effective drugs in hypertension. The present study was designed for comparative evaluation of BB with or without statins in the treatment of essential hypertension in a tertiary health care setup. Methods: This study was conducted in 20 hypertensive patients by Pharmacology Department in Medicine outpatient department at SGRRIM and HS Dehradun for 1 year. Initially, patients were stabilized for 4 weeks by BB and then subdivided into 2 groups. Group I: BB (n=10) and Group II: BB+statins (n=10). Patients were followed up every 4 weeks for 16 weeks. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), waist hip ratio (WHR), body mass index (BMI) were done every visit. Lipid profile was done at 4 and 16 weeks. Analysis was performed using t test. p≤0.05 was significant. Results: At 4 and 16 weeks, SBP in Group I was 133.6±3.7 and 127±1.61 mmHg (p>0.05) and in Group II was 141.2±2.97 and 130.6±0.71 mmHg (p<0.01). At 4 and 16 weeks DBP in Group I was 79.6±2.37 and 81±0.54 mmHg (p>0.05) and in Group II was 84.6±1.39 and 83.8±1.45 mmHg (p>0.05), respectively. At 16 weeks intergroup SBP and DBP comparison was done, which was not significant (p>0.05). At 4 and 16 weeks improvement in lipid profile in Group I (p>0.05) was not significant, but a significant improvement in Group II (p<0.05) have been observed and no significant changes in BMI and WHR in Groups I and II (p>0.05), respectively. Conclusions: Both groups showed significant improvement in BP. However, no significant difference was seen on intergroup comparison. Larger studies with more patients are needed to establish the role of statins in hypertension.en_US
dc.identifier.citationBawa Shalu, Dutta Shakti B, Kumar Hitender, Beg Mirza Atif, Varma Amit, Anjoom Mohammad. Comparative evaluation of beta-blockers with or without statins in the treatment of essential hypertension at a tertiary health care setup. International Journal of Basic & Clinical Pharmacology. 2015 Jan-Feb; 4(1): 125-129.en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/165003
dc.language.isoenen_US
dc.source.urihttps://www.ijbcp.com/?mno=174781en_US
dc.subjectBeta-blockersen_US
dc.subjectBlood pressureen_US
dc.subjectEssential hypertensionen_US
dc.subjectLipid profileen_US
dc.subjectStatinsen_US
dc.titleComparative evaluation of beta-blockers with or without statins in the treatment of essential hypertension at a tertiary health care setup.en_US
dc.typeArticleen_US
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