Comparative evaluation of beta-blockers with or without statins in the treatment of essential hypertension at a tertiary health care setup.
Loading...
Date
2015-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: The effects of statins apart from their role as cholesterol lowering agents
have prompted this study to evaluate their antihypertensive role. Beta-blockers (BB)
are one of the most effective drugs in hypertension. The present study was designed
for comparative evaluation of BB with or without statins in the treatment of essential
hypertension in a tertiary health care setup.
Methods: This study was conducted in 20 hypertensive patients by Pharmacology
Department in Medicine outpatient department at SGRRIM and HS Dehradun for
1 year. Initially, patients were stabilized for 4 weeks by BB and then subdivided
into 2 groups. Group I: BB (n=10) and Group II: BB+statins (n=10). Patients were
followed up every 4 weeks for 16 weeks. Systolic blood pressure (SBP) and diastolic
blood pressure (DBP), waist hip ratio (WHR), body mass index (BMI) were done
every visit. Lipid profile was done at 4 and 16 weeks. Analysis was performed using
t test. p≤0.05 was significant.
Results: At 4 and 16 weeks, SBP in Group I was 133.6±3.7 and 127±1.61 mmHg
(p>0.05) and in Group II was 141.2±2.97 and 130.6±0.71 mmHg (p<0.01). At 4
and 16 weeks DBP in Group I was 79.6±2.37 and 81±0.54 mmHg (p>0.05) and in
Group II was 84.6±1.39 and 83.8±1.45 mmHg (p>0.05), respectively. At 16 weeks
intergroup SBP and DBP comparison was done, which was not significant (p>0.05). At
4 and 16 weeks improvement in lipid profile in Group I (p>0.05) was not significant,
but a significant improvement in Group II (p<0.05) have been observed and no
significant changes in BMI and WHR in Groups I and II (p>0.05), respectively.
Conclusions: Both groups showed significant improvement in BP. However, no
significant difference was seen on intergroup comparison. Larger studies with more
patients are needed to establish the role of statins in hypertension.
Description
Keywords
Beta-blockers, Blood pressure, Essential hypertension, Lipid profile, Statins
Citation
Bawa Shalu, Dutta Shakti B, Kumar Hitender, Beg Mirza Atif, Varma Amit, Anjoom Mohammad. Comparative evaluation of beta-blockers with or without statins in the treatment of essential hypertension at a tertiary health care setup. International Journal of Basic & Clinical Pharmacology. 2015 Jan-Feb; 4(1): 125-129.