Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide

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dc.contributor.authorSene, Men_US
dc.contributor.authorDiouf, Ien_US
dc.contributor.authorNdiaye, Men_US
dc.contributor.authorBa, Aen_US
dc.contributor.authorNdiaye, Aen_US
dc.contributor.authorKane, MOen_US
dc.contributor.authorSarr, Men_US
dc.contributor.authorSchini-kerth, Ven_US
dc.contributor.authorSene, M.en_US
dc.date.accessioned2025-08-13T09:57:11Z
dc.date.available2025-08-13T09:57:11Z
dc.date.issued2025-03
dc.description.abstractBackground: Elaeis guineensis is a plant of the Arecaceae family that is used in traditional medicine in Senegal to treat high blood pressure. However, to our knowledge, there is no scientific evidence supporting its ability to lower blood pressure in hypertensive patients. Aim: The objective of this study was to provide a scientific basis for the use of this plant as a remedy for high blood pressure in traditional medicine. Methods: We in vitro evaluated the endothelium-dependent vasorelaxant capacity of a methanolic fraction of E. guineensis leaf powder (MSEG01). To achieve this, rings of pig coronary arteries with and without endothelium are mounted in isolated organ chambers. After stabilization for approximately 1 hour, the rings were precontracted with U46619 and then exposed to a range of increasing concentrations of MSEG01 ranging from 1 to 100 ?g/ml. For some experiments, the rings were incubated with different inhibitors (L-NA, INDOMETHACIN, TRAM-34 +UCL) to determine the cell signaling pathways involved in MSEG01-induced relaxation. Results: The results showed that MSEG01 causes relaxation in a model of coronary arteries in pigs previously contracted with U46619. For rings with endothelium, a relaxation start was noted at 3 ?g/ml, and the maximum relaxation (90%) was obtained at 100 ?g/ml. Without endothelium, MSEG01 does not induce relaxation. Conclusion: This study explains the use of E. guineensis for the management and prevention of high blood pressure and cardiovascular complications in traditional medicine in Senegal. However, additional research is needed to ensure its safety for human health.en_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Senegalen_US
dc.identifier.affiliationsUnit of Training and Research in Health Sciences, Assane Seck University of Ziguinchor, Ziguinchor, Senegalen_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Senegalen_US
dc.identifier.affiliationsFaculty of Health and Sustainable Development, Alioune Diop University, Bambey, Senegalen_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Senegalen_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Senegalen_US
dc.identifier.affiliationsLaboratoire de Physiologie Pharmaceutique, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Senegalen_US
dc.identifier.affiliationsTranslational Cardiovascular Medicine, Strasbourg Biomedical Research Centre, Strasbourg University, Strasbourg, Franceen_US
dc.identifier.affiliationsLaboratoire de Pharmacologie et Pharmacodynamie, Faculté de Médecine, de Pharmacie et d’Odontologie, Université Cheikh Anta Diop, Dakar, Senegalen_US
dc.identifier.citationSene M, Diouf I, Ndiaye M, Ba A, Ndiaye A, Kane MO, Sarr M, Schini-kerth V, Sene M.. Vasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxide . National Journal of Physiology, Pharmacy and Pharmacology. 2025 Mar; 15(3): 253-257en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/252841
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber3en_US
dc.relation.volume15en_US
dc.source.urihttps://dx.doi.org/10.5455/NJPPP.2025.v15.i3.6en_US
dc.subjectElaeis guineensisen_US
dc.subjectVasorelaxant effectsen_US
dc.subjectPorcine coronary.en_US
dc.titleVasorelaxant effects of methanolic fraction leaves powder extract of Elaeis guineensis in porcine coronary arteries: Possible involvement of Nitric Oxideen_US
dc.typeJournal Articleen_US
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