Importance of Urine Culture and Antibiotic Sensitivity for Improving Clinicians’ Choice in Treating Urinary Tract Infections

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dc.contributor.authorMannari, JGen_US
dc.contributor.authorKanjariya, Gen_US
dc.contributor.authorShah, MKen_US
dc.contributor.authorModi, Cen_US
dc.contributor.authorGanjiwale, J.en_US
dc.date.accessioned2025-05-12T09:38:08Z
dc.date.available2025-05-12T09:38:08Z
dc.date.issued2024-12
dc.description.abstractBackground: The local antibiogram is essential to prevent the development of multidrug-resistant organisms. The aim of the study was to find out the synchronization of empirical antibiotics with the sensitivity pattern of the urine culture report and to study the differences in the organisms and sensitivity patterns in urinary tract infection (UTI) with and without other comorbidities. Materials and methods: UTI, diagnosed by a positive urine culture report of 300 consecutive patients above the age of 18, was studied retrospectively. The data were processed using the statistical software STATA 14. Results: Out of 300 patients, 58.3% were females. The mean [standard deviation (SD)] age was 54.19 (19.06) years. The most common associated comorbidity was diabetes mellitus (DM) (34.7%). Lower urinary tract symptoms (LUTS) were the most common presenting symptom, followed by dysuria and fever. The most common organism was Escherichia coli in both nondiabetic and diabetic patients (67.3% and 60.6%). Comparing diabetics and nondiabetics, recurrent UTI (15.4 vs 5.1%), infection with extended-spectrum beta-lactamase (ESBL) organisms (67.3 vs 51.5%), and prolonged hospitalization (75 vs 61.2%) were observed more in diabetics. The most common empirical antibiotic chosen was cefoperazone-sulbactam in the diabetic group and levofloxacin in the nondiabetic group. Empirical antibiotics in diabetics matched with the sensitivity in 57.1% of ESBL cases and 47% of non-ESBL cases, while in nondiabetics, this alignment was 40.5% in ESBL cases and 61% in non-ESBL cases. Resistance to oral fluoroquinolone, cotrimoxazole, and nitrofurantoin was 78, 59.3, and 39.6%, respectively, while resistance to meropenem and amikacin was 35.6 and 25.6%. Conclusion: The increasing prevalence of ESBL-positive strains and rising resistance to common antimicrobial drugs raise concerns for future therapeutic options.en_US
dc.identifier.affiliationsProfessor, Department of Medicine, Pramukhswami Medical College, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, Indiaen_US
dc.identifier.affiliationsAssistant Professor, Department of Medicine, Pramukhswami Medical College, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, Indiaen_US
dc.identifier.affiliationsSenior Consultant Nephrologist and Transplant Physician, Associate Professor, Department of Medicine, Pramukhswami Medical College, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Microbiology, Pramukhswami Medical College, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Central Research Services and Department of Community Medicine, Pramukhswami Medical College, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, Indiaen_US
dc.identifier.citationMannari JG, Kanjariya G, Shah MK, Modi C, Ganjiwale J.. Importance of Urine Culture and Antibiotic Sensitivity for Improving Clinicians’ Choice in Treating Urinary Tract Infections. Journal of the Association of Physicians of India. 2024 Dec; 72(12): 30-34en_US
dc.identifier.issn0004-5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247331
dc.languageenen_US
dc.publisherJournal of Indian Medical Associationen_US
dc.relation.issuenumber12en_US
dc.relation.volume72en_US
dc.source.urihttps://doi.org/10.59556/japi.72.0783en_US
dc.titleImportance of Urine Culture and Antibiotic Sensitivity for Improving Clinicians’ Choice in Treating Urinary Tract Infectionsen_US
dc.typeJournal Articleen_US
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