Bioluminescence assay of adenosine triphosphate in drug susceptibility testing of Mycobacterium tuberculosis.

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dc.contributor.authorKumar, Ven_US
dc.contributor.authorSelvakumar, Nen_US
dc.contributor.authorVenkatesan, Pen_US
dc.contributor.authorChandrasekaran, Ven_US
dc.contributor.authorParamasivan, C Nen_US
dc.contributor.authorPrabhakar, Ren_US
dc.date.accessioned1998-02-16en_US
dc.date.accessioned2009-05-27T06:24:56Z
dc.date.available1998-02-16en_US
dc.date.available2009-05-27T06:24:56Z
dc.date.issued1998-02-16en_US
dc.description.abstractTwenty three clinical isolates M. tuberculosis and the reference strain, M. tuberculosis H37Rv were tested for their susceptibility to trifluoperazine (TFP) by the standard broth dilution method and the bioluminescence assay. The results showed that in 15 of the 23 isolates, the minimal inhibitory concentration (MIC) was identical in both the methods and in the remaining 8 isolates the difference in the MIC values between the methods, was less than two fold and was not significant. The findings suggest that the measurement of adenosine triphosphate (ATP) by bioluminescence assay can be employed as an alternative method for the rapid screening of clinical isolates for their susceptibility to anti-mycobacterial agents.en_US
dc.description.affiliationTuberculosis Research Centre, Chennai.en_US
dc.identifier.citationKumar V, Selvakumar N, Venkatesan P, Chandrasekaran V, Paramasivan CN, Prabhakar R. Bioluminescence assay of adenosine triphosphate in drug susceptibility testing of Mycobacterium tuberculosis. Indian Journal of Medical Research. 1998 Feb; 107(): 75-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16109
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdenosine Triphosphate --metabolismen_US
dc.subject.meshLuminescent Measurementsen_US
dc.subject.meshMicrobial Sensitivity Tests --methodsen_US
dc.subject.meshMycobacterium tuberculosis --drug effectsen_US
dc.subject.meshTrifluoperazine --pharmacologyen_US
dc.titleBioluminescence assay of adenosine triphosphate in drug susceptibility testing of Mycobacterium tuberculosis.en_US
dc.typeJournal Articleen_US
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