Anti tubercular treatment induced hepatotoxicity: does acetylator status matter?

Simple item page
dc.contributor.authorSingh, Jen_US
dc.contributor.authorGarg, P Ken_US
dc.contributor.authorThakur, V Sen_US
dc.contributor.authorTandon, R Ken_US
dc.date.accessioned1995-01-01en_US
dc.date.accessioned2009-06-01T06:07:38Z
dc.date.available1995-01-01en_US
dc.date.available2009-06-01T06:07:38Z
dc.date.issued1995-01-01en_US
dc.description.abstractAnti tubercular drug related hepatotoxicity is common. The mechanism of injury and factors predisposing to its development are not fully understood. Forty patients with anti tubercular drugs related hepatotoxicity were studied to see the clinical and biochemical profile of these patients and to find out the significance of acetylator phenotype in the development of hepatotoxicity. Mean age of patients with liver damage (37.82 +/- 10.0 years) was similar to those without liver damage (36.48 +/- 12.5 years). Pyrazinamide appeared to increase the hepatotoxicity of isoniazid and rifampicin. The percentage of rapid acetylators and slow acetylators among patients with hepatotoxicity (70% and 30% respectively) was similar to controls (66.6% rapid and 33.3% slow acetylators). Acetylator phenotype probably has no role in anti tubercular drugs induced hepatotoxicity.en_US
dc.description.affiliationDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSingh J, Garg PK, Thakur VS, Tandon RK. Anti tubercular treatment induced hepatotoxicity: does acetylator status matter? Indian Journal of Physiology and Pharmacology. 1995 Jan; 39(1): 43-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107145
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAcetylationen_US
dc.subject.meshAdulten_US
dc.subject.meshAntitubercular Agents --administration & dosageen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHepatitis, Toxic --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoniazid --administration & dosageen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPyrazinamide --administration & dosageen_US
dc.subject.meshRifampin --administration & dosageen_US
dc.titleAnti tubercular treatment induced hepatotoxicity: does acetylator status matter?en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology