Establishing Trimester-Specific Reference Ranges for Thyroid Hormones in Indian Women with Normal Pregnancy: New Light through Old Window

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dc.contributor.authorKulhari, Kanchanen_US
dc.contributor.authorNegi, Rakhien_US
dc.contributor.authorKalra, Dinesh Kumaren_US
dc.contributor.authorPaul, Shamik Kren_US
dc.date.accessioned2020-09-24T07:09:36Z
dc.date.available2020-09-24T07:09:36Z
dc.date.issued2019-04
dc.description.abstractIntroduction: Assessment of thyroid function duringpregnancy is important for assessing maternal and foetalwell being. However, the complex physiological alterationsoccurring during normal pregnancy cause thyroid hormonelevels to change. Hence, the interpretation of the thyroidprofile becomes difficult in pregnancy if normal referenceranges are not defined. Study objective was to determinetrimester specific reference ranges for thyroid hormone innormal pregnancy.Material and methods: Serum sample was collected from194 females in various trimester of normal intrauterine singlepregnancy and total T3, total T4 and TSH was determined.The results obtained were then analysed to determine gestationspecific thyroid hormone levels.Result: The normal ranges of thyroid hormone in first, secondand third trimesters during normal pregnancy in our studywere: total T3 (83.9-196.6, 86.1-217.4, 79.9-186 ng/dl), totalT4 (4.4-11.5, 4.9-12.2, 5.1-13.2 μg/dl) and TSH (0.1-2.7, 0.4-3.3, 0.5-3.8 IU/ml) respectively.Conclusion: The levels of thyroid hormones in pregnancynot only show characteristic changes from non pregnant statebut also vary with each trimester. Hence, trimester specificreference ranges for thyroid hormone need to be defined toensure correct interpretation of these tests.en_US
dc.identifier.affiliationsClassified Specialist, Department of Laboratory Medicine, Command Hospital (WC), Chandimandiren_US
dc.identifier.affiliationsClassified Specialist, Department of Laboratory Medicine, Command Hospital (WC), Chandimandiren_US
dc.identifier.affiliationsClassified Specialist, Department of Laboratory Medicine, Command Hospital (WC), Chandimandiren_US
dc.identifier.affiliationsClassified Specialist, SR Neuroanaesthesia, Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, Indiaen_US
dc.identifier.citationKulhari Kanchan, Negi Rakhi, Kalra Dinesh Kumar, Paul Shamik Kr. Establishing Trimester-Specific Reference Ranges for Thyroid Hormones in Indian Women with Normal Pregnancy: New Light through Old Window. International Journal of Contemporary Medical Research . 2019 Apr; 6(4): d1-d4en_US
dc.identifier.issn2393-915X
dc.identifier.issn2454-7379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/202294
dc.languageenen_US
dc.publisherInternational Society for Contemporary Medical Researchen_US
dc.relation.issuenumber4en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.21276/ijcmr.2019.6.4.9en_US
dc.subjectTrimesteren_US
dc.subjectThyroid Hormonesen_US
dc.subjectNormal Pregnancyen_US
dc.titleEstablishing Trimester-Specific Reference Ranges for Thyroid Hormones in Indian Women with Normal Pregnancy: New Light through Old Windowen_US
dc.typeJournal Articleen_US
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