Modification of platelet shape change parameter by oxidized lipoprotein from beta-thalassemia/Hemoglobin E.

Simple item page
dc.contributor.authorSutipornpalangkul, Werasaken_US
dc.contributor.authorUnchern, Supeenunen_US
dc.contributor.authorSanvarinda, Yupinen_US
dc.contributor.authorChantharaksri, Udomen_US
dc.contributor.authorFucharoen, Suthaten_US
dc.date.accessioned2009-05-27T21:58:49Z
dc.date.available2009-05-27T21:58:49Z
dc.date.issued2009-04-21en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Beta-thalassemia/Hemoglobin E (beta-thal/Hb E) is a congenital hemolytic anemia that is prevalent in Thailand Pulmonary arterial occlusion is the cause of morbidity and mortality in these patients. Abnormality of platelets has been implicated as pathogenesis of this condition. However the blood-borne factors that induce platelet activation are not identified Recently, oxidized low-density lipoproteins (ox-LDLs) had been identified in thalassemic blood. OBJECTIVE: Identify whether oxidized LDL is the blood bone factor that induce platelet activation in beta-thal/Hb E patients. MATERIAL AND METHOD: Platelet activation was measured by monitoring platelet shape change parameter using plasma-free human platelets. The shape change parameter was monitored following exposure to normal LDL, oxidized LDL, and thalassemic LDL. RESULTS: Oxidized LDL, but not the native LDL and thalassemic LDL, showed platelet activation activity. Oxidation of thalassemic LDL with copper give rise to oxidized LDL with platelet activating activity. However less copper was needed by LDL from splenectomized beta-thal/Hb E patients than those from nonsplencectomized beta-thal/Hb E patients. CONCLUSION: LDL from splenectomized beta-thal/Hb E patients is more susceptible for oxidation and gives rise to oxidized-LDL that plays an important role in thrombosis event in these patients.en_US
dc.description.affiliationDepartment of Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. tewsv@mahidol.ac.then_US
dc.identifier.citationSutipornpalangkul W, Unchern S, Sanvarinda Y, Chantharaksri U, Fucharoen S. Modification of platelet shape change parameter by oxidized lipoprotein from beta-thalassemia/Hemoglobin E. Journal of the Medical Association of Thailand. 2009 Apr; 92(4): 504-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45737
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.titleModification of platelet shape change parameter by oxidized lipoprotein from beta-thalassemia/Hemoglobin E.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand