Exploration of antileishmanial activity in heterocycles; results of their in vivo & in vitro bioevaluations.

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dc.contributor.authorBhatnagar, Sen_US
dc.contributor.authorGuru, P Yen_US
dc.contributor.authorKatiyar, J Cen_US
dc.contributor.authorSrivastava, Ren_US
dc.contributor.authorMukherjee, Aen_US
dc.contributor.authorAkhtar, M Sen_US
dc.contributor.authorSeth, Men_US
dc.contributor.authorBhaduri, A Pen_US
dc.date.accessioned1989-11-01en_US
dc.date.accessioned2009-05-27T07:10:10Z
dc.date.available1989-11-01en_US
dc.date.available2009-05-27T07:10:10Z
dc.date.issued1989-11-01en_US
dc.description.abstractA total of 51 imidazoles, pyrroles, quinolines and isoxazolines compounds were screened for antileishmanial activity in vivo and in vitro, using Leishmania donovani as the test parasite. The screening revealed hitherto unknown antileishmanial activity in these heterocycles. Three of the compounds screened (one belonging to isoxazoline series and two from pyrrole series) showed significant anti-leishmanial activity, ranging from 86-91 per cent inhibition in hamsters. When tested in vitro, using macrophage amastigote culture system, these compounds showed inhibition of 62-78 per cent at 30 micrograms/ml concentration.en_US
dc.identifier.citationBhatnagar S, Guru PY, Katiyar JC, Srivastava R, Mukherjee A, Akhtar MS, Seth M, Bhaduri AP. Exploration of antileishmanial activity in heterocycles; results of their in vivo & in vitro bioevaluations. Indian Journal of Medical Research. 1989 Nov; 89(): 439-44en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19589
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiprotozoal Agents --pharmacologyen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshHeterocyclic Compounds --pharmacologyen_US
dc.subject.meshLeishmania donovani --drug effectsen_US
dc.subject.meshLeishmaniasis, Visceral --drug therapyen_US
dc.subject.meshMaleen_US
dc.titleExploration of antileishmanial activity in heterocycles; results of their in vivo & in vitro bioevaluations.en_US
dc.typeJournal Articleen_US
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