Action of some amides of substituted ethylenediamines on central nervous system.

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dc.contributor.authorSethi, O Pen_US
dc.contributor.authorIsmail, A Men_US
dc.contributor.authorBhavsar, G Cen_US
dc.contributor.authorTrivedi, B Men_US
dc.contributor.authorGulati, O Den_US
dc.date.accessioned1987-04-01en_US
dc.date.accessioned2009-06-01T07:54:37Z
dc.date.available1987-04-01en_US
dc.date.available2009-06-01T07:54:37Z
dc.date.issued1987-04-01en_US
dc.description.abstractFive of the substituted ethylenediamine amides (LMG I to V) were tested for various CNS attributes and for acute toxicity (24 hr mortality). All compounds were potent analgesics in various animal tests, LMG V being most potent. All reduced spontaneous activity of mice and potentiated ether anaesthesia. However, CAR was not altered and anti-MES were not pronounced in rats. Compounds appear to have a wide safety margin considering ED50 and LD50 in mice.en_US
dc.description.affiliationDepartment of Pharmacology, L.M. College of Pharmacy, Navarangpura, Ahmedabad.en_US
dc.identifier.citationSethi OP, Ismail AM, Bhavsar GC, Trivedi BM, Gulati OD. Action of some amides of substituted ethylenediamines on central nervous system. Indian Journal of Physiology and Pharmacology. 1987 Apr-Jun; 31(2): 125-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108515
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAmides --pharmacologyen_US
dc.subject.meshAnalgesics --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCentral Nervous System --drug effectsen_US
dc.subject.meshEthylenediamines --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshLethal Dose 50en_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshReflex --drug effectsen_US
dc.titleAction of some amides of substituted ethylenediamines on central nervous system.en_US
dc.typeJournal Articleen_US
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