Low-cost assays for monitoring HIV infected individuals in resource-limited settings.

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dc.contributor.authorBalakrishnan, Pachamuthu
dc.contributor.authorIqbal, Hussain Syed
dc.contributor.authorShanmugham, Saravanan
dc.contributor.authorMohanakrishnan, Janardhanan
dc.contributor.authorSolomon, Sunil S
dc.contributor.authorMayer, Kenneth H
dc.contributor.authorSolomon, Suniti
dc.date.accessioned2012-03-27T08:55:51Z
dc.date.available2012-03-27T08:55:51Z
dc.date.issued2011-12
dc.description.abstractUse of a combination of CD4 counts and HIV viral load testing in the management of antiretroviral therapy (ART) provides higher prognostic estimation of the risk of disease progression than does the use of either test alone. The standard methods to monitor HIV infection are flow cytometry based for CD4+ T cell count and molecular assays to quantify plasma viral load of HIV. Commercial assays have been routinely used in developed countries to monitor ART. However, these assays require expensive equipment and reagents, well trained operators, and established laboratory infrastructure. These requirements restrict their use in resource-limited settings where people are most afflicted with the HIV-1 epidemic. With the advent of low-cost and/or low-tech alternatives, the possibility of implementing CD4 count and viral load testing in the management of ART in resource-limited settings is increasing. However, an appropriate validation should have been done before putting them to use for patient testing.en_US
dc.identifier.citationBalakrishnan Pachamuthu, Iqbal Hussain Syed, Shanmugham Saravanan, Mohanakrishnan Janardhanan, Solomon Sunil S, Mayer Kenneth H, Solomon Suniti. Low-cost assays for monitoring HIV infected individuals in resource-limited settings. Indian Journal of Medical Research. 2011 Dec; 134(6): 823-834.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/137344
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284092/en_US
dc.subjectCD4 counten_US
dc.subjectHIV monitoringen_US
dc.subjectlow-cost assaysen_US
dc.subjectplasma viral loaden_US
dc.subjectresource-limited settingsen_US
dc.subject.meshCD4 Lymphocyte Count --economics
dc.subject.meshCD4 Lymphocyte Count --methods
dc.subject.meshCD4 Lymphocyte Count --standards
dc.subject.meshDeveloping Countries
dc.subject.meshDisease Progression
dc.subject.meshHIV Infections --diagnosis
dc.subject.meshHIV Infections --immunology
dc.subject.meshHIV-1
dc.subject.meshHumans
dc.subject.meshMonitoring, Immunologic --methods
dc.subject.meshPrognosis
dc.subject.meshViral Load --economics
dc.subject.meshViral Load --methods
dc.subject.meshViral Load --standards
dc.titleLow-cost assays for monitoring HIV infected individuals in resource-limited settings.en_US
dc.typeArticleen_US
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