HIV-1 Drug Resistance Among Newly HIV-1 Infected Individuals Attending Tertiary Referral Center in Chennai, India.

Simple item page
dc.contributor.authorIqbal, Hussain Syed
dc.contributor.authorSolomon, Sunil Suhas
dc.contributor.authorSaravanan, Shanmugam
dc.contributor.authorVidya, Madhavan
dc.contributor.authorKumarasamy, Nagalingeswaran
dc.contributor.authorSolomon, Suniti
dc.contributor.authorBalakrishnan, Pachamuthu
dc.date.accessioned2013-08-08T06:25:53Z
dc.date.available2013-08-08T06:25:53Z
dc.date.issued2011-11
dc.description.abstractContext: In the era of free HAART, accessibility and availability of ARV has been dramatically increased in India. However, rates of treatment literacy and adherence appear to be sub-optimal. Therefore, it is essential to monitor the extent of primary drug resistance in such settings. Materials and Methods: Between July and October 2006, 18 anti-retroviral-naοve individuals were identified as recent infected by the BED-Capture enzyme immunoassay in a VCTC clinic in Chennai. Specimens from these individuals were subjected to genotypic drug resistance testing. Phylogenetic trees were generated using MEGA for Windows version 4.0 using neighbor-joining method. The significant differences in polymorphic mutation frequencies between the study specimens and established subtype C-specific polymorphisms were examined using the Chi-square test. Results: Amino acid substitution (K103N and V106MV) at drug resistance positions occurred in two (11%) isolates, conferring high-level resistance to the non-nucleoside reverse-transcriptase inhibitors nevirapine (NVP), efavirenz (EFV), delavirdine (DLV) and notably extensive genetic variations were observed. K122E (94.4%) and K49R/KR (11.1%) polymorphisms identified in this study have not been previously described in established subtype-C specific polymorphisms. The rate of polymorphisms showed marked difference at the locations V60, D121, V35, and D123 (P < 0.0001). All the sequences showed maximum homology with Indian HIV-1 subtype C reference strain C.IN.95IN21068. Conclusions: The finding of resistance to NNRTIs is of public health importance. There is an urgent need to establish surveillance for primary drug resistance in large scale. Further studies are required to determine the phenotype impact of newer polymorphic mutations in relation to drug resistance and viral fitness.en_US
dc.identifier.citationIqbal Hussain Syed, Solomon Sunil Suhas, Saravanan Shanmugam, Vidya Madhavan, Kumarasamy Nagalingeswaran, Solomon Suniti, Balakrishnan Pachamuthu. HIV-1 Drug Resistance Among Newly HIV-1 Infected Individuals Attending Tertiary Referral Center in Chennai, India. Indian Journal of Medical Sciences. 2011 Nov; 65(11) 488-496.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147801
dc.language.isoenen_US
dc.source.urihttps://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2011;volume=65;issue=11;spage=488;epage=496;aulast=Iqbalen_US
dc.subjectPrimary HIV-1 drug resistanceen_US
dc.subjectHIV-1 polymorphismsen_US
dc.subjectrecent HIV-1 infectionen_US
dc.titleHIV-1 Drug Resistance Among Newly HIV-1 Infected Individuals Attending Tertiary Referral Center in Chennai, India.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijms2011v65n11p488.pdf
Size:
511.42 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Medical Sciences