Genetic polymorphisms and implications for human diseases.

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dc.contributor.authorSripichai, Orapanen_US
dc.contributor.authorFucharoen, Suthaten_US
dc.date.accessioned2009-05-27T20:29:02Z
dc.date.available2009-05-27T20:29:02Z
dc.date.issued2007-02-23en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractAfter the sequencing of the human genome is done, enormous genomic information and high-throughput profiling technologies are used. Increased attention has been paid to applying this knowledge to get better understanding of inherited diseases and complex disorders. Single nucleotide polymorphisms (SNPs) are DNA sequence variations that occur when a single nucleotide in the genome sequence is altered SNPs are an important tool for the study of the human genome. Application of SNPs analysis to human disease permits exploration of the influence of genetic polymorphisms on disease susceptibility, drug sensitivity/resistance, and ultimately health care. Databases of SNPs provide a powerful resource for association studies that try to establish a relationship between a phenotype and regions of the genome. Genomic approaches have garnered so much attention and investment because they offer the potential to provide better understanding of genetic factors in human health and disease, as well as more-precise definitions of the non-genetic factors involved.en_US
dc.description.affiliationThalassemia Research Center, Institute of Science and Technology for Research and Development, Mahidol University, Phutthamonthon, Nakhonpathom, Thailand.en_US
dc.identifier.citationSripichai O, Fucharoen S. Genetic polymorphisms and implications for human diseases. Journal of the Medical Association of Thailand. 2007 Feb; 90(2): 394-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43081
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshGenetic Diseases, Inborn --geneticsen_US
dc.subject.meshGenome, Humanen_US
dc.subject.meshHumansen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshThalassemia --geneticsen_US
dc.titleGenetic polymorphisms and implications for human diseases.en_US
dc.typeJournal Articleen_US
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