Evaluation of the Anticonvulsant and Antidepressant Effects of the Aqueous Extract of the Leaves of Ascotheca paucinervia (T. Anderson ex C.B. Clarke) Heine in Mice

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dc.contributor.authorJudicaƫl, B. D.en_US
dc.contributor.authorRadar, O.en_US
dc.contributor.authorGelvid, O. N.en_US
dc.contributor.authorAntoine, A. A.en_US
dc.date.accessioned2023-07-14T08:07:05Z
dc.date.available2023-07-14T08:07:05Z
dc.date.issued2023-01
dc.description.abstractThe present study was undertaken to evaluate the anticonvulsant and antidepressant effects of Ascotheca paucinervia leaves on mice by using strychnine at 2.5mg/kg to induce convulsions and the forced swimming test to create a stressful situation, respectively. Concerning convulsions, only the 500mg/kg extract significantly increases (p<0.001) the time to onset of convulsions and it non-significantly reduces the duration of convulsions induced by strychnine. In addition, the extract reduces very significantly in a dose-dependent manner the time of immobility and it significantly increases the swimming time as well as the climbing time at both doses. At the same time, the estimation of the acute toxicity of the extract from the leaves of Ascotheca paucinervia according to guideline No. 425 of the OECD (2022) shows that the latter is weakly toxic and its LD50 is greater than 5000mg/kg. In addition, the evaluation of the sedative effect of this extract shows that it produces a dose-dependent sedative effects and at doses of 250m/kg and 500mg/kg, the extract significantly potentiates the sleep induced by phenobarbital. In summary, the results obtained suggest that Ascotheca paucineervia leaves extract possesses anticonvulsant and antidepressant effects.en_US
dc.identifier.affiliationsLaboratory of Pharmacodynamics and Experimental Physiopathology (L2PE), Faculty of Sciences and Technology, Marien Ngouabi University, BP: 69,Brazzaville, Congoen_US
dc.identifier.affiliationsBiochemistry and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, BP: 69,Brazzaville, Congoen_US
dc.identifier.citationJudicaƫl B. D., Radar O., Gelvid O. N., Antoine A. A.. Evaluation of the Anticonvulsant and Antidepressant Effects of the Aqueous Extract of the Leaves of Ascotheca paucinervia (T. Anderson ex C.B. Clarke) Heine in Mice. European Journal of Medicinal Plants. 2023 Jan; 34(1): 1-11en_US
dc.identifier.issn2231-0894
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219528
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume34en_US
dc.source.urihttps://doi.org/10.9734/ejmp/2023/v34i11115en_US
dc.subjectAnticonvulsant activityen_US
dc.subjectantidepressant activityen_US
dc.subjectepilepsyen_US
dc.subjectAscotheca paucinerviaen_US
dc.titleEvaluation of the Anticonvulsant and Antidepressant Effects of the Aqueous Extract of the Leaves of Ascotheca paucinervia (T. Anderson ex C.B. Clarke) Heine in Miceen_US
dc.typeJournal Articleen_US
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