Comparison of diagnostic capability of macular ganglion cell complex and retinal nerve fiber layer among primary open angle glaucoma, ocular hypertension, and normal population using Fourier‑domain optical coherence tomography and determining their functional correlation in Indian population.
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Date
2016-04
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Abstract
Context: Analysis of diagnostic ability of macular ganglionic cell complex and retinal nerve fiber
layer (RNFL) in glaucoma. Aim: To correlate functional and structural parameters and comparing predictive
value of each of the structural parameters using Fourier‑domain (FD) optical coherence tomography (OCT)
among primary open angle glaucoma (POAG) and ocular hypertension (OHT) versus normal population.
Setting and Design: Single centric, cross‑sectional study done in 234 eyes. Materials and Methods: Patients
were enrolled in three groups: POAG, ocular hypertensive and normal (40 patients in each group). After
comprehensive ophthalmological examination, patients underwent standard automated perimetry and
FD‑OCT scan in optic nerve head and ganglion cell mode. The relationship was assessed by correlating
ganglion cell complex (GCC) parameters with mean deviation. Results were compared with RNFL
parameters. Statistical Analysis: Data were analyzed with SPSS, analysis of variance, t‑test, Pearson’s
coefficient, and receiver operating curve. Results: All parameters showed strong correlation with visual
field (P < 0.001). Inferior GCC had highest area under curve (AUC) for detecting glaucoma (0.827) in POAG
from normal population. However, the difference was not statistically significant (P > 0.5) when compared
with other parameters. None of the parameters showed significant diagnostic capability to detect OHT from
normal population. In diagnosing early glaucoma from OHT and normal population, only inferior GCC had
statistically significant AUC value (0.715). Conclusion: In this study, GCC and RNFL parameters showed
equal predictive capability in perimetric versus normal group. In early stage, inferior GCC was the best
parameter. In OHT population, single day cross‑sectional imaging was not valuable.
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Keywords
Early diagnosis of glaucoma, Fourier‑domain‑optical coherence tomography, ganglion cell complex, retinal nerve fiber layer
Citation
Barua Nabanita, Sitaraman Chitra, Goel Sonu, Chakraborti Chandana, Mukherjee Sonai, Parashar Hemandra. Comparison of diagnostic capability of macular ganglion cell complex and retinal nerve fiber layer among primary open angle glaucoma, ocular hypertension, and normal population using Fourier‑domain optical coherence tomography and determining their functional correlation in Indian population. Indian Journal of Ophthalmology. 2016 Apr; 64(4): 296-302.