Isolation and partial structural evaluation of a cardiotoxic factor from Indian common murrel (Channa striatus L.) skin extract.

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dc.contributor.authorKarmakar, Sen_US
dc.contributor.authorDas, Tulikaen_US
dc.contributor.authorGhosh, Aen_US
dc.contributor.authorDasgupta, S Cen_US
dc.contributor.authorBiswas, A Ken_US
dc.contributor.authorGomes, Aen_US
dc.date.accessioned2009-05-28T10:51:58Z
dc.date.available2009-05-28T10:51:58Z
dc.date.issued2004-03-06en_US
dc.description.abstractIt was earlier reported from this laboratory that, Channa striatus, L a common edible fish, whose skin extract (CSSE) was pharmacologicaclly potent and contains several bioactive compounds. In the present communication a cardiotoxic factor was isolated and purified by thin layer chromatography followed by silica gel and neutral alumina column chromatography. Spectroscopic studies (UV, IR, 1H and 13C NMR, FAB-MS) indicated that the lethal cardiotoxic factor (CSS-CTF II) was an aromatic alkaloid compound with -NH, > C = C < and -OH functional groups. The molecular weight was found to be 413 dalton. LD50 of CSS-CTF II was found to be 42.5 mg/kg (i.v) in Swiss albino male mice. Pharmacological studies showed that CSS-CTF II possesses hypotensive and cardiotoxic activities and produced death through apnoea in experimental animals but had no effect on nerve muscle preparations. The haematological and biochemical data also indicated the toxic nature of CSS-CTF II, through significant fall in haemoglobin, total RBC, WBC, platelet count and increased cardiac marker enzyme CPK and CPK-MB value in experimental animals. The present investigation thus established the toxic nature of CSS-CTF II isolated from edible fish C. striatus skin extract. Further work is needed to identify CSS-CTF II's mechanism of action and its antagonism for therapeutic purpose.en_US
dc.description.affiliationLaboratory of Toxicology and Experimental Pharmacodynamics, Department of Physiology, University of Calcutta, 92, A.P.C. Road, Kolkata 700 009, India.en_US
dc.identifier.citationKarmakar S, Das T, Ghosh A, Dasgupta SC, Biswas AK, Gomes A. Isolation and partial structural evaluation of a cardiotoxic factor from Indian common murrel (Channa striatus L.) skin extract. Indian Journal of Experimental Biology. 2004 Mar; 42(3): 271-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55908
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshCarotid Arteries --drug effectsen_US
dc.subject.meshCatsen_US
dc.subject.meshChromatography, Thin Layeren_US
dc.subject.meshFish Venoms --chemistryen_US
dc.subject.meshFishesen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeart --drug effectsen_US
dc.subject.meshMagnetic Resonance Spectroscopyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshOxygen Consumption --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshSciatic Nerve --drug effectsen_US
dc.subject.meshSkin --metabolismen_US
dc.subject.meshSpectrophotometryen_US
dc.subject.meshSpectrophotometry, Infrareden_US
dc.subject.meshTime Factorsen_US
dc.subject.meshUltraviolet Raysen_US
dc.titleIsolation and partial structural evaluation of a cardiotoxic factor from Indian common murrel (Channa striatus L.) skin extract.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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