Effect of oophorectomy on expression of calcium sensing receptor mRNA in rat duodenal mucosa.

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dc.contributor.authorMehrotra, Men_US
dc.contributor.authorGupta, S Ken_US
dc.contributor.authorTiwari, Sen_US
dc.contributor.authorAgarwal, Aen_US
dc.contributor.authorKumar, Ken_US
dc.contributor.authorAwasthi, P Ken_US
dc.contributor.authorGodbole, M Men_US
dc.date.accessioned2009-05-28T15:03:36Z
dc.date.available2009-05-28T15:03:36Z
dc.date.issued2003-01-23en_US
dc.description.abstractCalcium sensing receptor (CaR) in duodenal mucosa may be involved in active calcium absorption. Estrogen deficiency results in decreased intestinal calcium absorption. Effects of bilateral oophorectomy (OVX) have been studied on calcium homeostasis, bone mineral density (BMD) and CaR mRNA levels in duodenal mucosa at 4 weeks in adult female Sprague Dawley rats and compared with those in sham-operated and control group. There was no significant change in serum corrected calcium, inorganic phosphorous, calcidiol and intact parathyroid hormone in all the three groups. OVX rats had a significant decline in serum estrogen (E2) levels and alkaline phosphatase. They also had a significant decrease in BMD (DXA) at lumbar spine in vivo, and proximal and distal tibia in vitro while there was no significant change in serum E2 and BMD parameters in sham-operated and control rats. Northern blot analysis revealed no significant change in the CaR mRNA expression in duodenal mucosa in all three groups. The results suggests that CaR mRNA expression in duodenal mucosa is not affected by physiological circulating concentrations of estradiol in rats.en_US
dc.description.affiliationDepartment of Medical Endocrinology, Centre for Endocrine Sciences, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India. sushil@sgpgi.ac.inen_US
dc.identifier.citationMehrotra M, Gupta SK, Tiwari S, Agarwal A, Kumar K, Awasthi PK, Godbole MM. Effect of oophorectomy on expression of calcium sensing receptor mRNA in rat duodenal mucosa. Indian Journal of Experimental Biology. 2003 Jan; 41(1): 41-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/61504
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Densityen_US
dc.subject.meshDuodenum --metabolismen_US
dc.subject.meshEstrogens --deficiencyen_US
dc.subject.meshFemaleen_US
dc.subject.meshIntestinal Mucosa --metabolismen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshRNA, Messenger --geneticsen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Calcium-Sensing --geneticsen_US
dc.titleEffect of oophorectomy on expression of calcium sensing receptor mRNA in rat duodenal mucosa.en_US
dc.typeJournal Articleen_US
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