Studies on antidiabetic activity of Acacia ferruginea DC. stem bark .

Simple item page
dc.contributor.authorDeb, Jhuma
dc.contributor.authorSingh, Anoop
dc.contributor.authorRathore, Devendra Singh
dc.contributor.authorDash, Gouri Kumar
dc.contributor.authorDeb, Nilip Kanti
dc.date.accessioned2016-12-09T10:47:21Z
dc.date.available2016-12-09T10:47:21Z
dc.date.issued2015-10
dc.description.abstractThe methanol extract of Acacia ferruginea (Family- Mimosaceae) was studied for possible antidiabetic activity on normoglycaemic, OGTT and alloxan induced diabetic rats at doses of 100, 200, and 400 mg/kg, p.o. The acute toxicity studies were carried out on Swiss albino mice to determine the LD50 values. The experiments were performed as per OECD guidelines. The results of the normoglycaemic, OGTT and hyperglycaemic studies revealed that the extract exhibited reduction in blood glucose concentration in a dose dependant manner as compared to the standard drug metformin (250 mg/kg, p.o.). The acute toxicity studies revealed no signs of mortality in animals treated with a single dose of 2000 mg/kg body weight. Preliminary phytochemical studies of the methanol extract revealed presence of alkaloids, steroids, triterpenoids, saponins, flavonoids, tannins and phenolic compounds, carbohydrates, gums and mucilages, proteins and amino acids. The present study justifies the use of the plant for treating diabetes as suggested in folklore remedies.en_US
dc.identifier.citationJhuma Deb1, Anoop Singh1 , Devendra Singh Rathore1 , Gouri Kumar Dash2 , Nilip Kanti Deb1. Studies on antidiabetic activity of Acacia ferruginea DC. stem bark. Indian Journal of Pharmaceutical & Biological Research. 2015 Oct-Dec; 3(4): 11-15.en_US
dc.identifier.issn2320-9267
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/179649
dc.language.isoenen_US
dc.source.urihttps://ijpbr.in/pdf/3-Studies-on-antidiabetic-activity-of-Acacia-ferruginea-DC-stem-bark.pdfen_US
dc.subjectAcacia ferrugineaen_US
dc.subjectAlloxanen_US
dc.subjectMetforminen_US
dc.subjectAntidiabeticen_US
dc.titleStudies on antidiabetic activity of Acacia ferruginea DC. stem bark .en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpbr2015v3n4p11.pdf
Size:
75.66 KB
Format:
Adobe Portable Document Format
Description:
Original Research article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Pharmaceutical & Biological Research