Atorvastatin improves arterial stiffness in normotensive normolipidaemic persons with type 2 diabetes.

Simple item page
dc.contributor.authorMukherjee, Sarmisthaen_US
dc.contributor.authorMukhopadhyay, Pradipen_US
dc.contributor.authorPandit, Kaushiken_US
dc.contributor.authorMukherjee, Satinathen_US
dc.contributor.authorChowdhury, Subhankaren_US
dc.date.accessioned2008-11-17en_US
dc.date.accessioned2009-05-31T11:37:13Z
dc.date.available2008-11-17en_US
dc.date.available2009-05-31T11:37:13Z
dc.date.issued2008-11-17en_US
dc.description.abstractIncreased arterial stiffness is an independent predictor of cardiovascular disease and mortality in middle-aged and olderadults. We measured arterial stiffness by pulse wave velocity (PWV)in brachial-ankle segments by automated oscillometry in 71 normotensive and normolipidaemic subjects with type 2 diabetes (40 males and 31 females). 57 patients (whose baPWV was more than 1400 cm/second) were randomised into two groups, group A (n=29) were given 10 mg atorvastatin daily for 6 months and group B (n=28) were given placebo. After 6 months, atorvastatin group had significant improvement in brachial-ankle pulse wave velocity (baPWV) (1712.03 +/- 349.9 cm/second versus 1558.81 +/- 303.26 cm/ second, p< 0.05). Though the placebo group showed some improvement (1692.03 +/- 425.15 cm/second versus 1636.78 +/- 425.1 cm/second) it was not statistically significant. Despite correlation was noted between baPWV and systolic blood pressure (SBP), there was no significant correlation between the mean baPWV and duration of diabetes, body mass index (BMI), waist circumference, waist-hip ratio (WHR), waist to height ratio (WHtR), glycated haemoglobin (HbA1c), LDL, HDL cholesterol and spot urine albumin creatinine ratio (ACR) at the baseline. The decrement of LDL-cholesterol is correlated with the decrement of the baPWV in the atorvastatin group only (p<0.01).en_US
dc.description.affiliationDepartment of of Endocrinology, IPGME&R and SSKM Hospital, Kolkata.en_US
dc.identifier.citationMukherjee S, Mukhopadhyay P, Pandit K, Mukherjee S, Chowdhury S. Atorvastatin improves arterial stiffness in normotensive normolipidaemic persons with type 2 diabetes. Journal of the Indian Medical Association. 2008 Nov; 106(11): 716-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/100382
dc.language.isoengen_US
dc.source.urihttps://www.jimaonline.org.in/en_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnkle --blood supplyen_US
dc.subject.meshAnticholesteremic Agents --administration & dosageen_US
dc.subject.meshArteriosclerosis --complicationsen_US
dc.subject.meshBlood Flow Velocity --drug effectsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshBrachial Artery --drug effectsen_US
dc.subject.meshCholesterol, HDL --drug effectsen_US
dc.subject.meshCholesterol, LDL --drug effectsen_US
dc.subject.meshDiabetes Mellitus, Type 2 --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeptanoic Acids --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulsatile Flow --drug effectsen_US
dc.subject.meshPyrroles --administration & dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAtorvastatin improves arterial stiffness in normotensive normolipidaemic persons with type 2 diabetes.en_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Indian Medical Association