Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats.

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dc.contributor.authorDhuley, Jayant Nen_US
dc.date.accessioned2002-02-06en_US
dc.date.accessioned2009-05-27T04:14:40Z
dc.date.available2002-02-06en_US
dc.date.available2009-05-27T04:14:40Z
dc.date.issued2002-02-06en_US
dc.description.abstractRhinax, a polyherbal formulation, exhibited hepatoprotective function when tested against antitubercular drug-induced hepatotoxicity in rats. Suppression of GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and glutathione S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in cytochrome P-450 contents and increased production of lipid peroxidation. Rhinax afforded hepatoprotection by inhibiting lipid peroxidation and, as a result, the animals showed improved antioxidant status.en_US
dc.description.affiliationPharmacology and Toxicology Section, Research and Development Division, Hindustan Antibiotics Ltd., Pimpri, Pune 411 018, India. dr_jaynil@yahoo.comen_US
dc.identifier.citationDhuley JN. Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats. Hindustan Antibiotics Bulletin. 2002 Feb-Nov; 44(1-4): 53-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/2339
dc.language.isoengen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntitubercular Agents --toxicityen_US
dc.subject.meshHepatitis, Toxic --enzymologyen_US
dc.subject.meshHerbal Medicineen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshLiver --enzymologyen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMedicine, Ayurvedicen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleHepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats.en_US
dc.typeJournal Articleen_US
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