Intellectual Disability in Indian Children: Experience with a Stratified Approach for Etiological Diagnosis.
| dc.contributor.author | Jain, Silky | |
| dc.contributor.author | Chowdhury, Veena | |
| dc.contributor.author | Juneja, Monica | |
| dc.contributor.author | Kabra, Madhulika | |
| dc.contributor.author | Pandey, Sanjeev | |
| dc.contributor.author | Singh, Ankur | |
| dc.contributor.author | Bhattacharya, Malobika | |
| dc.contributor.author | Kapoor Seema | |
| dc.date.accessioned | 2016-01-07T05:50:38Z | |
| dc.date.available | 2016-01-07T05:50:38Z | |
| dc.date.issued | 2013-12 | |
| dc.description.abstract | Objective: To study the clinico-etiological profile of children with intellectual disability using an algorithmic approach. Design: Cross-sectional study. Setting: Tertiary care centre in Northern India. Participants: Consecutive children aged 3 months to 12 years, presenting with intellectual disability, confirmed by Developmental Assessment Scale for Indian Infants, Binet Kulshreshtha Test and Vineland Social Maturity Scale. Method: All children were assessed on an internally validated structured proforma. A targeted approach included thyroid function tests, Brainstem evoked response audiometry, electroencephalogram, neuroimaging and metabolic screen done as a pre-decided schema. Genetic tests included karyotyping, molecular studies for Fragile X, Multiplex Ligation Dependent Probe Amplification and Array Comparative Genomic Hybridisation. Results: Data of 101 children (median age 22 months) was analyzed. The etiological yield was 82.1% with genetic causes being the most common (61.4%) followed by perinatal acquired (20.4%), CNS malformations (12%), external prenatal (3.6%), and postnatal acquired (2.4%). Mild delay was seen in 11.7%, moderate in 21.7%, severe in 30.6% and profound in 35.6%. Conclusion: It is possible to ascertain the diagnosis in most of the cases of intellectual disability using a judicious and sequential battery of tests. | en_US |
| dc.identifier.citation | Jain Silky, Chowdhury Veena, Juneja Monica, Kabra Madhulika, Pandey Sanjeev, Singh Ankur, Bhattacharya Malobika, Kapoor Seema. Intellectual Disability in Indian Children: Experience with a Stratified Approach for Etiological Diagnosis. Indian Pediatrics. 2013 December; 50(12): 1125-1130. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/170093 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.indianpediatrics.net/dec2013/dec-1125-1130.htm | en_US |
| dc.subject | Children | en_US |
| dc.subject | India | en_US |
| dc.subject | Etiology | en_US |
| dc.subject | Intellectual disability | en_US |
| dc.title | Intellectual Disability in Indian Children: Experience with a Stratified Approach for Etiological Diagnosis. | en_US |
| dc.type | Article | en_US |