Association of serum iron and serum calcium levels in children with febrile seizures

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dc.contributor.authorGupta, Hen_US
dc.contributor.authorSharma, Ben_US
dc.contributor.authorVerma, Men_US
dc.contributor.authorSingh, VKen_US
dc.contributor.authorVerma, R.en_US
dc.date.accessioned2025-05-09T09:48:19Z
dc.date.available2025-05-09T09:48:19Z
dc.date.issued2024-04
dc.description.abstractObjectives: The current case–control study was conducted to investigate the relationship of iron deficiency anemia and calcium levels with febrile seizures (FSs) in children. Materials and Methods: The study included 200 children ranging in age from 6 to 60 months. One hundred cases had FSs, including simple FSs and rest; 100 controls had a short history of febrile illness (<3 days) without seizures. A statistical analysis of the data was carried out using Statistical Package for the Social Sciences version 23. Results: The mean weight, height, and head circumference of cases and controls are 9.73 ± 2.51 kg and 10.63 ± 3.34 kg, 79.66 ± 11.08 cm and 85.43 ± 15.55 cm, and 46.37 ± 2.79 cm and 46.83 ± 3.72 cm, respectively. As per the Indian Academy of Pediatrics, 27% of cases and 37% of controls had protein energy malnutrition (PEM). In cases and controls, the mean hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width values were 9.23 ± 1.30 and 10.78 ± 1.60 gm/dL, 68.83 ± 8.86 and 78.59 ± 9.82 fl, 25.40 ± 3.47 and 28.50 ± 3.60 pg, and 18.73 ± 1.77 and 16.44 ± 1.76, respectively, and are statistically significant. Patients had lower serum ferritin levels than controls. The mean blood calcium levels in cases and controls were 9.13 ± 0.64 and 9.05 ± 0.93 mg/dL, respectively (P = 0.507). Iron deficiency anemia was found in 26% of cases and 7% of controls (P value <0.001). Hypocalcemia was reported in only 18% of patients and 23% of controls (P = 0.38). Conclusion: There is a clear correlation between FSs and iron deficiency. The majority of data suggests that hypocalcemia is unlikely to be the cause of FSs. Early detection and intervention of iron deficiency in children could help in the prevention and recurrence of FSs.en_US
dc.identifier.affiliationsDepartment of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, King George’s Medical University, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pediatrics, Baba Raghav Das (BRD) Medical College, Gorakhpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India.en_US
dc.identifier.citationGupta H, Sharma B, Verma M, Singh VK, Verma R.. Association of serum iron and serum calcium levels in children with febrile seizures. Indian Journal of Medical Sciences. 2024 Apr; 76(1): 17-21en_US
dc.identifier.issn1998-3654
dc.identifier.issn0019-5359
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/244944
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber1en_US
dc.relation.volume76en_US
dc.source.urihttps://dx.doi.org/10.25259/IJMS_136_2023en_US
dc.subjectAnemiaen_US
dc.subjectHypocalcemiaen_US
dc.subjectChildrenen_US
dc.subjectFebrile seizuresen_US
dc.subjectCase–control studyen_US
dc.titleAssociation of serum iron and serum calcium levels in children with febrile seizuresen_US
dc.typeJournal Articleen_US
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