Dosimetric evaluation and clinical outcome in post-operative patients of carcinoma vulva treated with intensity-modulated radiotherapy.

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dc.contributor.authorKhosla, D
dc.contributor.authorPatel, F D
dc.contributor.authorShukla, A K
dc.contributor.authorRai, B
dc.contributor.authorOinam, A S
dc.contributor.authorSharma, S C
dc.date.accessioned2016-08-26T09:57:09Z
dc.date.available2016-08-26T09:57:09Z
dc.date.issued2015-10
dc.description.abstractBACKGROUND: To compare dosimetric parameters of intensity‑modulated radiation therapy (IMRT) with 3D conformal radiotherapy (3DCRT) in post‑operative patients of vulvar cancer and to assess clinical outcome and toxicity with IMRT. MATERIALS AND METHODS: A total of 8 post‑operative patients of vulvar cancer were treated with IMRT. All patients were also planned by 3DCRT for comparison with IMRT. The two plans were compared in terms of conformity index, homogeneity index, tumor control probability (TCP) and normal tissue complication probability (NTCP) for the planning target volume and organs at risk (OAR). RESULTS: IMRT resulted in significantly lesser doses to rectum, bladder, bowel and femoral head as compared with 3DCRT plans. Mean conformity and homogeneity indices were better and within range with IMRT. The TCP was comparable between the two treatment plans and NTCP for rectum, bladder, bowel and femoral head was significantly less with IMRT as compared with 3DCRT. Treatment was well‑tolerated and none of the patients developed Grade 3 or higher toxicity. CONCLUSION: IMRT yielded superior plans with respect to target coverage, homogeneity and conformality while lowering dose to adjacent OAR as compared with 3DCRT. Thus, IMRT offers a reduction in NTCP while maintaining TCP.en_US
dc.identifier.citationKhosla D, Patel F D, Shukla A K, Rai B, Oinam A S, Sharma S C. Dosimetric evaluation and clinical outcome in post-operative patients of carcinoma vulva treated with intensity-modulated radiotherapy. Indian Journal of Cancer. 2015 Oct-Dec; 52(4): 670-675.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/176714
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2015;volume=52;issue=4;spage=670;epage=674;aulast=Khoslaen_US
dc.subjectIntensity modulated radiation therapyen_US
dc.subjectnormal tissue complication probabilityen_US
dc.subjecttumor control probabilityen_US
dc.subjectvulvar canceren_US
dc.subject3D conformal radiotherapyen_US
dc.titleDosimetric evaluation and clinical outcome in post-operative patients of carcinoma vulva treated with intensity-modulated radiotherapy.en_US
dc.typeArticleen_US
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