Beneficial effects of long-term metoprolol therapy on cardiac haemodynamics in patients with mitral stenosis in sinus rhythm--a randomised clinical trial.

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dc.contributor.authorKumar, Ren_US
dc.contributor.authorSaran, R Ken_US
dc.contributor.authorDwivedi, S Ken_US
dc.contributor.authorNarain, V Sen_US
dc.contributor.authorPuri, V Ken_US
dc.contributor.authorHasan, Men_US
dc.contributor.authorChandra, Nen_US
dc.contributor.authorAgrawal, Aen_US
dc.contributor.authorSinha, Nen_US
dc.contributor.authorAhuja, R Cen_US
dc.date.accessioned1994-11-01en_US
dc.date.accessioned2009-05-27T04:18:09Z
dc.date.available1994-11-01en_US
dc.date.available2009-05-27T04:18:09Z
dc.date.issued1994-11-01en_US
dc.description.abstractWe conducted a placebo controlled randomised clinical trial to evaluate the effects of 6 months therapy with metoprolol on resting and exercise haemodynamics in 31 patients with isolated mitral stenosis in sinus rhythm. Twenty six of them (placebo n = 13, metoprolol n = 13) completed the study protocol. Their mean age was 23.1 +/- 7.9 years and the mean mitral valve area was 0.93 +/- 0.25 cm2. The dose of metoprolol ranged between 50-100 mg per day. The primary outcome variables for the study were the resting and exercise mean pulmonary capillary wedge pressure (PCWP) and cardiac index (CI) and the secondary outcome variables consisted of resting and exercise heart rate, mean pulmonary artery pressure (PAP), mean pulmonary vascular resistance (PVR) and clinical improvement on visual analog scale. These outcome variables were assessed blindly. The resting and exercise mean PCWP (mmHg) increased by 9.1 +/- 3.1 and 16.4 +/- 6.4 on placebo and 2.5 +/- 2.1 and -4.6 +/- 2.3 on metoprolol after 6 months therapy. These differences were statistically significant (p < 0.01). The resting and exercise CI (liters/min/m2) decreased by 0.2 +/- 0.1 and 0.1 +/- 0.1 on placebo and 0.3 +/- 0.5 and 0.3 +/- 1.0 on metoprolol. These haemodynamic effects were accompanied with much better symptomatic improvement in patients treated with metoprolol. The differences in change in mean PAP and PVR in two groups were statistically not significant. Our results suggest that the symptomatic patients with MS, waiting for definitive intervention for 6 months or less, would benefit if given beta blockers during this period.en_US
dc.description.affiliationDepartment of Cardiology & Medicine, K.G's Medical College, Lucknow.en_US
dc.identifier.citationKumar R, Saran RK, Dwivedi SK, Narain VS, Puri VK, Hasan M, Chandra N, Agrawal A, Sinha N, Ahuja RC. Beneficial effects of long-term metoprolol therapy on cardiac haemodynamics in patients with mitral stenosis in sinus rhythm--a randomised clinical trial. Indian Heart Journal. 1994 Nov-Dec; 46(6): 297-301en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/3064
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshExercise Tolerance --drug effectsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Catheterizationen_US
dc.subject.meshHemodynamics --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetoprolol --administration & dosageen_US
dc.subject.meshMitral Valve Stenosis --diagnosisen_US
dc.subject.meshPulmonary Wedge Pressure --drug effectsen_US
dc.subject.meshRheumatic Heart Disease --diagnosisen_US
dc.subject.meshTime Factorsen_US
dc.titleBeneficial effects of long-term metoprolol therapy on cardiac haemodynamics in patients with mitral stenosis in sinus rhythm--a randomised clinical trial.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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