Basal and FSH-stimulated Inhibin B in Precocious Puberty

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dc.contributor.authorChaudhary, Shakunen_US
dc.contributor.authorWalia, Ramaen_US
dc.contributor.authorBhansali, Anilen_US
dc.contributor.authorDayal, Devien_US
dc.contributor.authorSachdeva, Nareshen_US
dc.contributor.authorSingh, Tulikaen_US
dc.contributor.authorBhadada, Sanjay Kumaren_US
dc.date.accessioned2025-05-09T10:00:41Z
dc.date.available2025-05-09T10:00:41Z
dc.date.issued2024-08
dc.description.abstractObjective: To evaluate the role of basal and follicle-stimulating hormone (FSH)-stimulated inhibin B in differentiating premature thelarche from gonadotropin-dependent precocious puberty (GDPP). Method: This was a prospective interventional study. Basal and FSH-stimulated inhibin B levels were estimated in girls presenting with thelarche < 8 years age (n = 10), healthy girls with normal pubertal development (pubertal control) (n = 8) and healthy prepubertal girls (prepubertal control) (n = 7). Girls with early puberty were classified as premature thelarche or GDPP based on GnRH agonist stimulation test. Results: Median (IQR) basal inhibin B levels (pg/mL) in premature thelarche was 5.42 (2.91, 30.58) and FSH-stimulated inhibin B was 236.72 (111.53, 4431.73) (P = 0.043). Median (IQR) basal inhibin B in GDPP was 64.11 (24.96, 792.45) pg/mL and FSH- stimulated inhibin B was 833.66 (500.11-1266.18) pg/mL (P = 0.043). Basal inhibin B was discriminatory between GDPP and premature thelarche (P = 0.032). Median (IQR) basal inhibin B in prepubertal and pubertal controls was 20.36 (9.61, 29.12) and 75.48 (58.55, 165.55) pg/mL, respectively. Conclusion: Basal inhibin B is useful in differentiation of premature thelarche from GDPP while the role of FSH-stimulated inhibin B needs to be further explored in large sample size.en_US
dc.identifier.affiliationsDepartments of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartments of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartments of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsPediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartments of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsRadiology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartments of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.citationChaudhary Shakun, Walia Rama, Bhansali Anil, Dayal Devi, Sachdeva Naresh, Singh Tulika, Bhadada Sanjay Kumar . Basal and FSH-stimulated Inhibin B in Precocious Puberty. Indian Pediatrics. 2024 Aug; 61(8): 756-759en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245711
dc.languageenen_US
dc.publisherThe Indian Academy of Pediatricsen_US
dc.relation.issuenumber8en_US
dc.relation.volume61en_US
dc.source.urihttps://indianpediatrics.net/aug2024/756.pdfen_US
dc.subjectInhibin Ben_US
dc.subjectFSH stimulated inhibin Ben_US
dc.subjectPrecocious pubertyen_US
dc.subjectPremature thelarcheen_US
dc.titleBasal and FSH-stimulated Inhibin B in Precocious Pubertyen_US
dc.typeJournal Articleen_US
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