Basal and FSH-stimulated Inhibin B in Precocious Puberty

Objective: To evaluate the role of basal and follicle-stimulating hormone (FSH)-stimulated inhibin B in differentiating premature thelarche from gonadotropin-dependent precocious puberty (GDPP). Method: This was a prospective interventional study. Basal and FSH-stimulated inhibin B levels were estimated in girls presenting with thelarche < 8 years age (n = 10), healthy girls with normal pubertal development (pubertal control) (n = 8) and healthy prepubertal girls (prepubertal control) (n = 7). Girls with early puberty were classified as premature thelarche or GDPP based on GnRH agonist stimulation test. Results: Median (IQR) basal inhibin B levels (pg/mL) in premature thelarche was 5.42 (2.91, 30.58) and FSH-stimulated inhibin B was 236.72 (111.53, 4431.73) (P = 0.043). Median (IQR) basal inhibin B in GDPP was 64.11 (24.96, 792.45) pg/mL and FSH- stimulated inhibin B was 833.66 (500.11-1266.18) pg/mL (P = 0.043). Basal inhibin B was discriminatory between GDPP and premature thelarche (P = 0.032). Median (IQR) basal inhibin B in prepubertal and pubertal controls was 20.36 (9.61, 29.12) and 75.48 (58.55, 165.55) pg/mL, respectively. Conclusion: Basal inhibin B is useful in differentiation of premature thelarche from GDPP while the role of FSH-stimulated inhibin B needs to be further explored in large sample size.

Keywords

Inhibin B, FSH stimulated inhibin B, Precocious puberty, Premature thelarche

Citation

Chaudhary Shakun, Walia Rama, Bhansali Anil, Dayal Devi, Sachdeva Naresh, Singh Tulika, Bhadada Sanjay Kumar . Basal and FSH-stimulated Inhibin B in Precocious Puberty. Indian Pediatrics. 2024 Aug; 61(8): 756-759

URI

https://imsear.searo.who.int/handle/123456789/245711

Collections

Indian Pediatrics

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