Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing.

Simple item page
dc.contributor.authorUdupa, S Len_US
dc.contributor.authorShetty, Somashekaren_US
dc.contributor.authorUdupa, A Len_US
dc.contributor.authorSomayaji, S Nen_US
dc.date.accessioned2009-05-28T15:41:08Z
dc.date.available2009-05-28T15:41:08Z
dc.date.issued2006-01-25en_US
dc.description.abstractEthanolic extract of leaves of O. sanctum was investigated for normal wound healing and dexamethasone depressed healing using incision, excision and dead space wound models in albino rats. The extract of O. sanctum significantly increased the wound breaking strength in incision wound model. The extract treated wounds were found to epithelialize faster and the rate of wound contraction was significantly increased as compared to control wounds. Significant increase in wet and dry granulation tissue weight, granulation tissue breaking strength and hydroxyproline content in dead space wound model was observed. The extract significantly decreased the antihealing activities of dexamethasone in all the wound models. The results indicated that the leaf extract promotes wound healing significantly and able to overcome the wound healing suppressing action of dexamethasone. Histological examination of granulation tissue to determine the pattern of lay-down for collagen confirmed the results.en_US
dc.description.affiliationDepartment of Biochemistry, Kasturba Medical College, Manipal 576 104, India. s_udupa@yahoo.comen_US
dc.identifier.citationUdupa SL, Shetty S, Udupa AL, Somayaji SN. Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing. Indian Journal of Experimental Biology. 2006 Jan; 44(1): 49-54en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/62285
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6337/1/IJEB%2044%281%29%2049-54.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDexamethasone --toxicityen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshOcimumen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshWound Healing --drug effectsen_US
dc.subject.meshWounds and Injuries --drug therapyen_US
dc.titleEffect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology