Redefining the management of pediatric tonsillopharyngitis with cefprozil.

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dc.contributor.authorJerath, Nameeten_US
dc.contributor.authorShetty, Ganeshen_US
dc.date.accessioned2007-12-05en_US
dc.date.accessioned2009-05-30T12:40:07Z
dc.date.available2007-12-05en_US
dc.date.available2009-05-30T12:40:07Z
dc.date.issued2007-12-05en_US
dc.description33 references.en_US
dc.description.abstractTonsillopharyngitis is very common in children, with Group A Streptococci being the most common bacterial etiology. Effective antibacterial treatment is imperative due to risk of rheumatic fever. Cephalosporins have been used successfully for the treatment of Group A beta-hemolytic Streptococcal (GABHS) tonsillopharyngitis. Cefprozil is a novel broad-spectrum oral cephalosporin. Cefprozil is rapidly absorbed from the gastrointestinal tract with high bioavailability. The excellent penetration of cefprozil into tonsillar and adenoidal tissue corresponds well with the clinical outcome. The drug provides excellent coverage against both gram-negative and -positive bacteria that may cause pharyngitis/tonsillitis. The beta-lactamase stability of cefprozil appears to exceed that of other oral cephalosporins for important gram negative pathogens. In clinical trials, cefprozil appears to be at least as effective as commonly used comparison agents such as cefaclor and cefixime. Additionally, cefprozil is better tolerated than the latter, especially with regard to gastrointestinal adverse effects. Thus cefprozil can be considered a safe and reliable drug for the treatment of Streptococcal tonsillopharyngitis in children.en_US
dc.description.affiliationPediatric Intensivist, Indraprastha Apollo Hospital, New Delhi, India.en_US
dc.identifier.citationJerath N, Shetty G. Redefining the management of pediatric tonsillopharyngitis with cefprozil. Indian Journal of Pediatrics. 2007 Dec; 74(12): 1105-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/80918
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAnti-Bacterial Agents --administration & dosageen_US
dc.subject.meshCephalosporins --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshPharyngitis --drug therapyen_US
dc.subject.meshRandomized Controlled Trials as Topicen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshTonsillitis --drug therapyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleRedefining the management of pediatric tonsillopharyngitis with cefprozil.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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