Comparative evaluation of effi cacy and safety of carboxymethylcellulose either alone or in combination with non-steroidal anti-infl ammatory drug in the treatment of dry eye in a tertiary care teaching hospital.
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Date
2015-03
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Abstract
Background: Dry eye produces discomfort and reduced vision. The treatment of
dry eyes has traditionally involved hydrating and lubricating artifi cial tears. The
newer medications include non-steroidal anti-infl ammatory drugs (NSAIDs) for the
treatment of dry eye disorders. This study was designed to compare the effect of
topical carboxymethylcellulose (CMC) alone or in combination with topical NSAID
for the treatment of dry eye in a tertiary care teaching hospital.
Methods: A total of 60 patients diagnosed with dry eye were enrolled for a study
period of 1 year. Patient of either sex (male/female), age between 18 and 70 years,
and all diagnosed cases of dry eye in ophthalmology outpatient department were
selected. Patients (n=60) were stabilized on CMC for 2 weeks and thereafter divided
into two groups. Group I (n=30) received only topical CMC; Group II (n=30) received
CMC+NSAID. The patients were followed up to 12 weeks. Diagnostic tests included
Schirmer’s test and tear break up time (TBUT). Ocular Surface Disease Index (OSDI)
was used for assessing the Quality of Life. Analysis was done using GraphPad InStat
software. p<0.05 was considered signifi cant.
Results: This was an open-label study revealing a mean age of 46.0±1.79 years.
Females (56.67%) showed a signifi cantly higher prevalence of dry eye symptoms
compared to males (43.33%). The mean duration of illness was 1.95±0.16 years.
Schirmer’s test, TBUT test values and OSDI score in Group I and Group II at 0
and 12 weeks revealed signifi cant intragroup difference (p<0.0001). At 12 weeks
intergroup comparison in Schirmer’s test value (p>0.05) and TBUT test value (p>0.05)
showed no signifi cant difference while OSDI score revealed signifi cant difference
(p<0.05). Burning, stinging, blurring of vision, photophobia, and hyperemia were
among the common adverse effects seen.
Conclusion: Both groups showed signifi cant improvement in Schirmer’s test and
TBUT test value and OSDI score at the end of the study. Intergroup comparison
showed a signifi cant difference with reference to OSDI score. Patients receiving
NSAID reported more adverse effects.
Description
Keywords
Dry eye, Carboxymethylcellulose, Non-steroidal anti-infl ammatory drugs
Citation
Sindhu Saubhagya, Dutta Shakti B, Beg Mirza A, Mittal Sanjeev K, Gupta Sushobhan D. Comparative evaluation of effi cacy and safety of carboxymethylcellulose either alone or in combination with non-steroidal anti-infl ammatory drug in the treatment of dry eye in a tertiary care teaching hospital. International Journal of Basic & Clinical Pharmacology. 2015 Mar-Apr; 4(2): 245-249.