Comparative evaluation of various analgesic drugs in Wistar rats used as a teaching tool to teach animal experiments to post graduate MD Pharmacology students

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dc.contributor.authorBeg, Mirza Atifen_US
dc.contributor.authorDutta, Shakti Balaen_US
dc.contributor.authorKumar, Hitenderen_US
dc.contributor.authorSingh, Amandeepen_US
dc.contributor.authorBawa, Shaluen_US
dc.date.accessioned2020-04-23T07:53:00Z
dc.date.available2020-04-23T07:53:00Z
dc.date.issued2018-12
dc.description.abstractBackground: Postgraduates when join Pharmacology department, they don’t have much idea about guidelines and methods to do animal experiments. This study was designed to sensitize postgraduate students to animal experiments by evaluating the anti-inflammatory effects and the efficacy of diclofenac, tramadol and etoricoxib in reducing paw edema in wistar rats.Methods: The wistar rats of 225-250gram were divided into four groups (n=10 each). In all the groups the paw edema on right paw was created using 0.1ml of 1% formalin subcutaneously. Group 1 rats (control), group 2 were given diclofenac, group 3 were given tramadol and group 4 were given etoricoxib orally. The parameters assessed were water displacement in plethysmography after 2, 4, 24, 48 hours of giving the drug. The circumference of edematous paws after 4 hours, licking of paw was observed over 30minutes of giving the drug and was compared. Pre and post study feedback were obtained from the students by using a preformed questionnaire to assess the knowledge gained by the students.Results: The test showed that all the drugs were effective in reducing inflammation, circumference of edema and the licking duration significantly (p<0.05). The post study answering of questions by postgraduate was 100% in comparison to pre-study answering which was 33%.Conclusions: A short animal study conducted as a teaching tool to postgraduate students was able to teach the guidelines of animal experiments and handling of animals effectively.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttrakhand, Indiaen_US
dc.identifier.citationBeg Mirza Atif, Dutta Shakti Bala, Kumar Hitender, Singh Amandeep, Bawa Shalu. Comparative evaluation of various analgesic drugs in Wistar rats used as a teaching tool to teach animal experiments to post graduate MD Pharmacology students. International Journal of Basic & Clinical Pharmacology. 2018 Dec; 7(12): 2424-2428en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199948
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber12en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184859en_US
dc.subjectPaw edemaen_US
dc.subjectPaw lickingen_US
dc.subjectPlethysmographen_US
dc.titleComparative evaluation of various analgesic drugs in Wistar rats used as a teaching tool to teach animal experiments to post graduate MD Pharmacology studentsen_US
dc.typeJournal Articleen_US
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