Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis

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dc.contributor.authorSethi, Sen_US
dc.contributor.authorYadav, Ren_US
dc.contributor.authorSharma, Nen_US
dc.contributor.authorDadwal, Ren_US
dc.contributor.authorChaudary, Hen_US
dc.contributor.authorKaur, Ken_US
dc.contributor.authorSaini, Aen_US
dc.contributor.authorMalhotra, Sen_US
dc.contributor.authorRathore, Sen_US
dc.contributor.authorBagga, R.en_US
dc.date.accessioned2025-05-09T08:50:00Z
dc.date.available2025-05-09T08:50:00Z
dc.date.issued2024-06
dc.description.abstractBackground: Bacterial vaginosis is a common vaginal syndrome among females, which leads to significant morbidity and complications, if left untreated. The association of bacterial vaginosis with various sexually transmitted infections has been mentioned in previous literature. However, studies on the intermediate Nugent Score are lacking. This study was planned to examine the association of sexually transmitted infections with the intermediate Nugent Score. Materials and Methods: The study included was conducted to include females presenting with vaginal discharge, burning micturition, itching, lower abdominal pain and infertility. The Nugent scoring was used to categorize patients into those having normal flora, intermediate or bacterial vaginosis. Conventional and molecular techniques targeting Trichomonas vag- inalis, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Syphilis, Neisseria gonorrhoeae and vulvo- vaginal candidiasis were performed. Results: A total of 3,531 clinical samples were collected from females with a median age of 28.0 years. The number of pa- tients with bacterial vaginosis and intermediate Nugent Score and positive cases were significantly higher in the 21–35 years age group (P < 0.0001). We observed that the likelihood of test results being positive for Trichomonas vaginalis was higher (P < 0.05), as the abnormality of the vaginal flora increased. Mycoplasma hominis was observed to be significantly higher in the intermediate Nugent Score group than the BV-positive patients (0.6 vs 0.2, P = 0.002). The number of vulvovaginal candidia- sis cases in both the bacterial vaginosis-negative and bacterial vaginosis-positive groups were nearly the same (9.3 vs 9.8%). Limitations: Individual follow-up couldn’t be performed on the patients. Conclusions: We observed that the dysbiosis in vaginal microbiota, with an increase in Nugent scoring, was significantly associated with an increased risk for the acquisition of sexually transmitted infections and vulvovaginal candidiasis.en_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, CSIR-IMTECH, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, AIIMS, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medical Microbiology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.citationSethi S, Yadav R, Sharma N, Dadwal R, Chaudary H, Kaur K, Saini A, Malhotra S, Rathore S, Bagga R.. Association of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasis. Indian Journal of Dermatology, Venereology and Leprology. 2024 Jun; 90(3): 296-301en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/243756
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologistsen_US
dc.relation.issuenumber3en_US
dc.relation.volume90en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_775_2022en_US
dc.subjectBacterial vaginosisen_US
dc.subjectIntermediate nugent scoreen_US
dc.subjectMycoplasma hominisen_US
dc.subjectTrichomonas vaginalisen_US
dc.subjectVulvovaginal candidiasisen_US
dc.titleAssociation of intermediate Nugent Score and bacterial vaginosis with sexually transmitted infections and vulvovaginal candidiasisen_US
dc.typeJournal Articleen_US
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