Antimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells.

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dc.contributor.authorWongpa, Sareeyaen_US
dc.contributor.authorHimakoun, Lakanaen_US
dc.contributor.authorSoontornchai, Sarisaken_US
dc.contributor.authorTemcharoen, Punyaen_US
dc.date.accessioned2009-05-27T17:40:38Z
dc.date.available2009-05-27T17:40:38Z
dc.date.issued2007-10-12en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractPiperine is a major pungent substance and active component of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). Both plants are used worldwide as household spices and condiments. They are also used as important ingredients in folklore medicine in many Asian countries. Therefore, it is of interest to study antimutagenic effects of piperine. In this study, its influence on chromosomes was investigated in rat bone marrow cells. Male Wistar rats were orally administered piperine at the doses of 100, 400 and 800 mg/kg body weight for 24 hours then challenged with cyclophosphamide at a dose of 50 mg/kg body weight by intraperitoneal injection. Twenty-four hours thereafter, all animals were sacrificed and bone marrow samples were collected for chromosomal analysis. The results demonstrated that piperine at a dose of 100 mg/kg body weight gave a statistically significant reduction in cyclophosphamide-induced chromosomal aberrations. In conclusion, piperine may have antimutagenic potential. The underlying molecular mechanisms now require attention.en_US
dc.description.affiliationToxicology Graduate Programme, Faculty of Science, Mahidol University, Bangkok, Thailand. noo_toxmu@hotmail.comen_US
dc.identifier.citationWongpa S, Himakoun L, Soontornchai S, Temcharoen P. Antimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells. Asian Pacific Journal of Cancer Prevention. 2007 Oct-Dec; 8(4): 623-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37654
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAlkaloids --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimutagenic Agents --pharmacologyen_US
dc.subject.meshAntineoplastic Agents, Alkylating --toxicityen_US
dc.subject.meshBenzodioxoles --pharmacologyen_US
dc.subject.meshBone Marrow --drug effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshChromosome Aberrations --drug effectsen_US
dc.subject.meshCyclophosphamide --toxicityen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshMaleen_US
dc.subject.meshMitosis --drug effectsen_US
dc.subject.meshMitotic Indexen_US
dc.subject.meshPiper nigrum --chemistryen_US
dc.subject.meshPiperidines --pharmacologyen_US
dc.subject.meshPolyunsaturated Alkamides --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleAntimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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