Serum vitamin-D predicts insulin resistance in individuals with prediabetes.

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dc.contributor.authorDutta, Deep
dc.contributor.authorMaisnam, Indira
dc.contributor.authorShrivastava, Ankit
dc.contributor.authorSinha, Anirban
dc.contributor.authorGhosh, Sujoy
dc.contributor.authorMukhopadhyay, Pradip
dc.contributor.authorMukhopadhyay, Satinath
dc.contributor.authorChowdhury, Subhankar
dc.date.accessioned2015-01-13T09:49:46Z
dc.date.available2015-01-13T09:49:46Z
dc.date.issued2013-12
dc.description.abstractBackground & objectives: Patients with diabetes and vitamin-D insufficiency have increased insulin resistance. Similar observations among individuals with prediabetes are not well documented. The aim of this study was to find the occurrence of vitamin-D insufficiency/deficiency among individuals with prediabetes and to evaluate the relationship between vitamin-D status and insulin resistance. Methods: One hundred fifty seven individuals with prediabetes who fulfilled all the inclusion and exclusion criteria underwent clinical examination, anthropometric measurements (waist circumference, waist-hip ratio, waist-height ratio) and blood sampling after overnight fast for estimation of fasting blood glucose, fasting insulin, 25(OH)vitamin-D, intact parathyroid hormone (iPTH) and lipid profile. One hour post 75 g glucose (1hPG) blood glucose during oral glucose tolerance test was measured. Results: Vitamin-D deficiency/insufficiency was found in 115 (73.25%) individuals with prediabetes. Severe vitamin-D deficiency (<10 ng/ml) was seen in 14.65 per cent individuals. Individuals with the lowest vitamin-D levels (<10 ng/ml) had the highest insulin resistance (HOMA2-IR: 2.04 ± 0.67). Serum 25(OH)D had a statistically significant inverse correlation with insulin resistance (HOMA2-IR; r=-0.33; P=0.008), and positive correlation with insulin sensitivity (QUICKI; r=0.39; P=0.002), after adjusting for BMI and HbA1c. There was no correlation between vitamin-D status and estimated beta cell mass (HOMA-β). The mean waist-height ratio among individuals with prediabetes was 0.57 (normal<0.5) indicating a high risk of cardiovascular morbidity. Individuals with elevated 1hPG>155 mg/dl had significantly higher BMI and worse insulin resistance, and 1hPG correlated well with 2 hour post glucose blood glucose (r=0.57; P<0.001). Interpretations & conclusions: Vitamin-D deficiency/insufficiency may have some role in the development/worsening of insulin resistance in individuals with prediabetes in our country who have a high cardiovascular risk. Prospective studies on a large group of individuals need to be done to confirm the findings.en_US
dc.identifier.citationDutta Deep, Maisnam Indira, Shrivastava Ankit,Sinha Anirban, Ghosh Sujoy, Mukhopadhyay Pradip, Mukhopadhyay Satinath, Chowdhury Subhankar. Serum vitamin-D predicts insulin resistance in individuals with prediabetes. Indian Journal of Medical Research. 2013 Dec; 138(6): 853-860.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/155089
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978972/en_US
dc.subjectDeficiencyen_US
dc.subjectinsufficiencyen_US
dc.subjectinsulin resistanceen_US
dc.subjectone hour post glucose blood glucoseen_US
dc.subjectprediabetesen_US
dc.subjectvitamin-Den_US
dc.titleSerum vitamin-D predicts insulin resistance in individuals with prediabetes.en_US
dc.typeArticleen_US
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