Serum vitamin-D predicts insulin resistance in individuals with prediabetes.
dc.contributor.author | Dutta, Deep | |
dc.contributor.author | Maisnam, Indira | |
dc.contributor.author | Shrivastava, Ankit | |
dc.contributor.author | Sinha, Anirban | |
dc.contributor.author | Ghosh, Sujoy | |
dc.contributor.author | Mukhopadhyay, Pradip | |
dc.contributor.author | Mukhopadhyay, Satinath | |
dc.contributor.author | Chowdhury, Subhankar | |
dc.date.accessioned | 2015-01-13T09:49:46Z | |
dc.date.available | 2015-01-13T09:49:46Z | |
dc.date.issued | 2013-12 | |
dc.description.abstract | Background & objectives: Patients with diabetes and vitamin-D insufficiency have increased insulin resistance. Similar observations among individuals with prediabetes are not well documented. The aim of this study was to find the occurrence of vitamin-D insufficiency/deficiency among individuals with prediabetes and to evaluate the relationship between vitamin-D status and insulin resistance. Methods: One hundred fifty seven individuals with prediabetes who fulfilled all the inclusion and exclusion criteria underwent clinical examination, anthropometric measurements (waist circumference, waist-hip ratio, waist-height ratio) and blood sampling after overnight fast for estimation of fasting blood glucose, fasting insulin, 25(OH)vitamin-D, intact parathyroid hormone (iPTH) and lipid profile. One hour post 75 g glucose (1hPG) blood glucose during oral glucose tolerance test was measured. Results: Vitamin-D deficiency/insufficiency was found in 115 (73.25%) individuals with prediabetes. Severe vitamin-D deficiency (<10 ng/ml) was seen in 14.65 per cent individuals. Individuals with the lowest vitamin-D levels (<10 ng/ml) had the highest insulin resistance (HOMA2-IR: 2.04 ± 0.67). Serum 25(OH)D had a statistically significant inverse correlation with insulin resistance (HOMA2-IR; r=-0.33; P=0.008), and positive correlation with insulin sensitivity (QUICKI; r=0.39; P=0.002), after adjusting for BMI and HbA1c. There was no correlation between vitamin-D status and estimated beta cell mass (HOMA-β). The mean waist-height ratio among individuals with prediabetes was 0.57 (normal<0.5) indicating a high risk of cardiovascular morbidity. Individuals with elevated 1hPG>155 mg/dl had significantly higher BMI and worse insulin resistance, and 1hPG correlated well with 2 hour post glucose blood glucose (r=0.57; P<0.001). Interpretations & conclusions: Vitamin-D deficiency/insufficiency may have some role in the development/worsening of insulin resistance in individuals with prediabetes in our country who have a high cardiovascular risk. Prospective studies on a large group of individuals need to be done to confirm the findings. | en_US |
dc.identifier.citation | Dutta Deep, Maisnam Indira, Shrivastava Ankit,Sinha Anirban, Ghosh Sujoy, Mukhopadhyay Pradip, Mukhopadhyay Satinath, Chowdhury Subhankar. Serum vitamin-D predicts insulin resistance in individuals with prediabetes. Indian Journal of Medical Research. 2013 Dec; 138(6): 853-860. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/155089 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978972/ | en_US |
dc.subject | Deficiency | en_US |
dc.subject | insufficiency | en_US |
dc.subject | insulin resistance | en_US |
dc.subject | one hour post glucose blood glucose | en_US |
dc.subject | prediabetes | en_US |
dc.subject | vitamin-D | en_US |
dc.title | Serum vitamin-D predicts insulin resistance in individuals with prediabetes. | en_US |
dc.type | Article | en_US |
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