2D Echocardiographic Findings, NT-ProBNP Levels, and Outcomes in Dyspnoeic Patients: Results from the Pro-BNP Investigation of Dyspnoea in the Emergency Department- a Single Centre Experience

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dc.contributor.authorBalaraju, Den_US
dc.contributor.authorKumar, Ven_US
dc.contributor.authorKumar, Cen_US
dc.contributor.authorSetty, H. S. S. Nen_US
dc.contributor.authorSridhar, L. Sen_US
dc.contributor.authorKharge, Jen_US
dc.contributor.authorPatil, Ren_US
dc.contributor.authorManjunath, C. N.en_US
dc.date.accessioned2023-07-21T11:29:25Z
dc.date.available2023-07-21T11:29:25Z
dc.date.issued2022-09
dc.description.abstractBackground: Dyspnoeic in the emergency department with multiple co-morbidities is a diagnostic challenge. Approximately 15-20% of acute dyspneic in the Emergency Department due to ADHF (acute decompensated heart failure) are misdiagnosed. B-type peptide (BNP) and its amino-terminal fragment (NT-proBNP) accurately identify HF in dyspnoeic patients. In the general population with dyspnoea, plasma pro-BNP concentrations are increased in left ventricular dilatation, hypertrophy, systolic dysfunction, or diastolic dysfunction but are unaffected by pulmonary dysfunction. Aims and Objectives: To study the relation between NT pro-BNP & echocardiographic findings in acute dyspnoeic patients, and the relation between NT pro-BNP and In-hospital Mortality. Materials and Methods: Source of data- Patients admitted to the Emergency Room or cardiac intensive care unit with a history of acute dyspnea in a tertiary cardiac care center in south India, meeting inclusion & exclusion criteria, were studied. Results: The study population is predominantly constituted of the elderly population. The most common co-morbid condition was hypertension. The present study uses an NT pro BNP level of 900pg/ml as the cut-off level. 78 patients were positive for the test. Echocardiography showed that 58% had LV systolic dysfunction, 60% had diastolic dysfunction. 42 patients had EF >55%, 10 patients between 55-45%, 33 patients between 44-30% and 15 patients had EF < 30%. Mortality rate was 6% in the whole study population. However, Mortality was seen in only NT pro-BNP positive group it was not statistically significant (p=0.46). Conclusions: NT pro-BNP correlates well with the worsening of LV systolic function; as the EF decreases, NT pro-BNP increases. Increase in NT pro-BNP levels has to be interpreted in the clinical context, and it is not a substitute for echocardiography for assessing cardiac abnormalities and dysfunction.en_US
dc.identifier.affiliationsSri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationBalaraju D, Kumar V, Kumar C, Setty H. S. S. N, Sridhar L. S, Kharge J, Patil R, Manjunath C. N.. 2D Echocardiographic Findings, NT-ProBNP Levels, and Outcomes in Dyspnoeic Patients: Results from the Pro-BNP Investigation of Dyspnoea in the Emergency Department- a Single Centre Experience. Cardiology and Angiology: An International Journal. 2022 Sep; 11(4): 336-346en_US
dc.identifier.issn2347-520X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220273
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.9734/ca/2022/v11i4288en_US
dc.subjectDyspnoeicen_US
dc.subject2D-echocardiographyen_US
dc.subjectNT pro-BNPen_US
dc.title2D Echocardiographic Findings, NT-ProBNP Levels, and Outcomes in Dyspnoeic Patients: Results from the Pro-BNP Investigation of Dyspnoea in the Emergency Department- a Single Centre Experienceen_US
dc.typeJournal Articleen_US
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