Spironolactone; the ultimate blocker of RAAS cascade in hypertensive patients with special reference to its cardiovascular benefits: Revisiting the forgotten ways.
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Date
2012-04
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Acknowledgement: All the authors would like to express their heartfelt thanks to Dr Jagadeesh Tangudu,
Mtech, MS, PhD and Sowmya Jammula, M Tech for their immense and selfless contribution towards manuscript
preparation, language editing and final approval of text. Abstract: Hypertension is a major risk factor
for various macro and microvascular complications in a patient with diabetes. Control of hypertension
is of paramount importance in the care of a diabetes subject. The goals for blood pressure in diabetes subjects
are below 130/ 80 mmHg and below 125/75 mmHg if accompanying renal impairment is there.
Spironolactone is a medication that has been used to treat high blood pressure since the 1960s. While there
is some belief spironolactone reduces blood pressure, there are concerns due to the potential for this drug to
cause adverse effects. Previous Meta analysis has shown that spironolactone reduces systolic/diastolic blood
pressure by approximately 20/7 mmHg compared to placebo. Spironolactone has also been shown to
decrease morbidity and mortality in patients with heart failure. We have tried to emphasize upon the usage
of this old but important drug in management of resistant hypertension with reference to its mode of action,
benefits and recent studies pertinent to cardiovascular benefits of spironolactone. Data Source:We searched
PUBMED and MEDLINE database for relevant articles including key words. References of each article
were further reviewed for final synthesis of the manuscript.
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Keywords
Hypertension, microvascular, macrovascular, spironolactone
Citation
K K Sunil, Sruti J, Siva K K, Sandip P, Lalit K M, Kirtikumar D M. Spironolactone; the ultimate blocker of RAAS cascade in hypertensive patients with special reference to its cardiovascular benefits: Revisiting the forgotten ways. Bangladesh Journal of Medical Science. 2012; 11(2): 80-86.